Skip to search formSkip to main contentSkip to account menu

insulin-like growth factor 2, human

Known as: insulinlike growth factor II, human, IGF-II, Somatomedin A 
Insulin-like growth factor II (180 aa, ~20 kDa) is encoded by the human IGF2 gene. This protein plays a role in cellular growth, development, and… 
National Institutes of Health

Related topics

Related topics

13 relations
Biological MarkersCell Proliferation Regulatory ProcessExtracellular SpaceGrowth Factor

Broader (1)

insulin-like growth factor 2

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation.
Although IGF-II activating the IGF-II receptor signaling pathway has been found to stimulate cardiomyocyte hypertrophy, the role… 
Highly Cited
2004
Highly Cited
2004
Placental-specific insulin-like growth factor 2 (Igf2) regulates the diffusional exchange characteristics of the mouse placenta.
Restricted fetal growth is associated with postnatal mortality and morbidity and may be directly related to alterations in the… 
Highly Cited
2001
Highly Cited
2001
Stimulation of human extravillous trophoblast migration by IGF-II is mediated by IGF type 2 receptor involving inhibitory G protein(s) and phosphorylation of MAPK.
We have earlier shown that migration and invasiveness of first trimester human extravillous trophoblast cells are stimulated by… 
Highly Cited
1998
Highly Cited
1998
Autocrine-paracrine regulation of human trophoblast invasiveness by insulin-like growth factor (IGF)-II and IGF-binding protein (IGFBP)-1.
Trophoblast growth and invasion of the uterus are tightly regulated by locally produced factors. Since insulin-like growth factor… 
Highly Cited
1996
Highly Cited
1996
Insulin-like growth factor I receptor prevents apoptosis and enhances neuroblastoma tumorigenesis.
Autocrine stimulation of the type I insulin-like growth factor receptor (IGF-IR) by IGF-II is one mechanism that allows cancer… 
Highly Cited
1995
Highly Cited
1995
Disruption of imprinting caused by deletion of the H19 gene region in mice
The imprinted H19 gene, which encodes an untranslated RNA, lies at the end of a cluster of imprinted genes in the mouse… 
Highly Cited
1991
Highly Cited
1991
Isolation of a novel insulin-like growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGF-II in human bone.
Highly Cited
1990
Highly Cited
1990
Experimental Diabetes Increases Insulinlike Growth Factor I and II Receptor Concentration and Gene Expression in Kidney
Insulinlike growth factor I (IGF-I) is a mitogenic hormone with important regulatory roles in growth and development. One of the… 
Highly Cited
1986
Highly Cited
1986
Insulin-like growth factors I and II in fetal and adult bovine serum. Purification, primary structures, and immunological cross-reactivities.
Insulin-like growth factors I and II (IGF-I and IGF-II) were prepared from fetal calf serum and adult bovine serum by gel… 
Highly Cited
1985
Highly Cited
1985
Nucleotide sequences of cDNAs encoding precursors of human insulin‐like growth factor II (IGF‐II) and an IGF‐II variant
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)