Skip to search formSkip to main contentSkip to account menu

indotecan

Known as: 5H-(1,3)dioxolo(4',5':5,6)indeno(1,2-c)isoquinoline-5,12(6H)-dione, 2,3-dimethoxy-6-(3-(4-morpholinyl)propyl)- 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

NSC 724998

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Abstract 4855: Indotecan (LMP400), Imidotecan (LMP776) and LMP744: A new class of non-camptothecin TOP1 inhibitors selective for cancer cells with homologous recombination deficiencies and high…
To relax DNA supercoiling, topoisomerase I (TOP1) induces DNA cleavage complexes (TOP1cc). These TOP1cc can be trapped by… 
2017
2017
Abstract 2794: Indotecan (LMP400), imidotecan (LMP776) and LMP744: A new class of non-camptothecin Top1 inhibitors selective for homologous recombination deficient (HRD) cells
To relax DNA supercoiling during transcription and replication, topoisomerase I (Top1) induces transient DNA cleavage complexes… 
2015
2015
Abstract 4513: Pharmacokinetics and pharmacodynamics of indenoisoquinoline LMP400 (Indotecan) in BALB/c female mice bearing CT-26 colon tumors
Introduction: The indenoisoquinoline, LMP400 (NSC743400, indotecan), is currently in Phase I clinical trials for the treatment of… 
2012
2012
Indotecan (LMP400) and AM13-55: Two Novel Indenoisoquinolines Show Potential for Treating Visceral Leishmaniasis
ABSTRACT Visceral leishmaniasis is an emerging neglected tropical disease (NTD) caused by the protozoan Leishmania infantum in… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)