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indole biosynthetic process

Known as: indole formation, indole anabolism, indole biosynthesis 
The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g… Expand
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Indole synthesis – something old, something new
Indoles, both naturally occurring and synthetic, exhibit wide-ranging biological activity. Unusual and complex molecular… Expand
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Highly Cited
2013
Highly Cited
2013
Rhodium(III)-catalyzed indole synthesis using N-N bond as an internal oxidant.
We report herein a Rh(III)-catalyzed cyclization of N-nitrosoanilines with alkynes for streamlined synthesis of indoles. The… Expand
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Highly Cited
2013
Highly Cited
2013
Indole synthesis by rhodium(III)-catalyzed hydrazine-directed C-H activation: redox-neutral and traceless by N-N bond cleavage.
Fishing for complements! There is an alternative to the useful Fischer indole synthesis. The new method utilizes the same… Expand
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Highly Cited
2012
Highly Cited
2012
Palladium-catalyzed aerobic oxidative cyclization of N-aryl imines: indole synthesis from anilines and ketones.
We report here an operationally simple, palladium-catalyzed cyclization reaction of N-aryl imines, affording indoles via the… Expand
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Highly Cited
2010
Highly Cited
2010
Mechanistically driven development of iridium catalysts for asymmetric allylic substitution.
Enantioselective allylic substitution reactions comprise some of the most versatile methods for preparing enantiomerically… Expand
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Highly Cited
2008
Highly Cited
2008
Palladium-catalyzed oxidative cyclization of N-aryl enamines: from anilines to indoles.
The indole unit is one of the most abundant and relevant heterocycles in natural products and pharmaceuticals. Despite the… Expand
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Highly Cited
2008
Highly Cited
2008
Dirhodium(II)-catalyzed intramolecular C-H amination of aryl azides.
The development of new transition-metal-catalyzed methods for selective functionalization of carbon–hydrogen bonds continues to… Expand
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Highly Cited
2007
Highly Cited
2007
Enterohemorrhagic Escherichia coli Biofilms Are Inhibited by 7-Hydroxyindole and Stimulated by Isatin
ABSTRACT Since indole is present at up to 500 μM in the stationary phase and is an interspecies biofilm signal (J. Lee, A… Expand
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Highly Cited
2005
Highly Cited
2005
Synthesis and functionalization of indoles through palladium-catalyzed reactions.
The substituted indole nucleus [indole is the acronym from indigo (the natural dye) and oleum (used for the isolation)] is a… Expand
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Highly Cited
2004
Highly Cited
2004
Development of an efficient procedure for indole ring synthesis from 2-ethynylaniline derivatives catalyzed by CuII salts and its application to natural product synthesis.
The development of efficient methods for the indole synthesis catalyzed by Cu(II) salts and its applications were investigated… Expand
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