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Chiral Brønsted acid-catalyzed direct Mannich reactions via electrophilic activation.
It was found that the phosphoric acid derivatives of general structure 1 serve as highly effective catalysts for the direct addition of acetyl acetone to N-Boc-protected arylimines and functions as an excellent catalyst.
Axially chiral guanidine as enantioselective base catalyst for 1,4-addition reaction of 1,3-dicarbonyl compounds with conjugated nitroalkenes.
The axially chiral guanidine catalysts thus developed facilitated the highly enantioselective 1,4-addition reaction of 1,3-dicarbonyl compounds with a broad range of conjugated nitroalkenes and showed extremely high catalytic activity.
Synthetic Method for 2,2'-Disubstituted Fluorinated Binaphthyl Derivatives and Application as Chiral Source in Design of Chiral Mono-Phosphoric Acid Catalyst.
The catalyst (R)- performs exceptionally well in the catalytic enantioselective imino-ene reaction, demonstrating the potential of a fluorinated binaphthyl framework.
Aza-Henry reaction of ketimines catalyzed by guanidine and phosphazene bases
Abstract A general catalytic addition of nitromethane to simple N -diphenylphosphinoyl ketimines is achieved using either 10 mol % 1,1,3,3-tetramethylguanidine (TMG) or 10 mol % phosphazene ( t
Axially Chiral Guanidines as Efficient Bronsted Base Catalysts for Enantioselective Transformations
Asymmetric transformations catalyzed by small chiral organic molecules, the so-called enantioselective organocatalysis, have been developed as an efficient protocol for obtaining optically active
Chiral Phosphoric Acids asVersatile Catalysts for Enantioselective Transformations
Chiral phosphoric acids derived from axially chiral biar- yls and related chiral Bronsted acids have emerged as an attractive and widely applicable class of enantioselective organocatalysts for a