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indibulin

Known as: N-(Pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide, N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide 
A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

AcetamidesIndoles

Narrower (1)

D 24851
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
molbank Communication 2-[ 2-Methyl-5-phenyl-1-( 3 , 4 , 5-trimethoxyphenyl )-1 H-pyrrol-3-yl ]-2-oxoN-( pyridin-4-yl ) acetamide
We synthesized 2-[2-methyl-5-phenyl-1-(3,4,5-trimethoxyphenyl)-1H-pyrrol-3-yl]-2-oxoN-(pyridin-4-yl) acetamide 4 as a novel… 
2012
2012
Abstract P6-11-10: IBL2001: Phase I/II study of a novel dose-dense schedule of oral indibulin for the treatment of metastastic breast cancer.
Background: Indibulin (ZI0-301) is a novel, oral, synthetic small molecule microtubule inhibitor which binds tubulin at a… 
2012
2012
[Molecular dynamics simulation of the tubulin dimer with cytostatics].
Colchicin, podophylotoxin and indibulin are natural cytostatics that are used in the treatment of neoplasms. But applications of… 
2012
2012
IBL2001: Phase (ph) I/II study of a novel dose-dense (dd) schedule of indibulin for the treatment of metastastic breast cancer.
TPS1143 Background: Indibulin (Zybulin, ZIO‑301) is a new, synthetic agent that inhibits tumor cell growth at the G2/M phase… 
2010
2010
Gateways to clinical trials.
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide… 
2008
2008
A novel oral tubulin inhibitor: Safety and preliminary efficacy of two Phase I studies with indibulin
B4 Purpose: Indibulin is a novel oral tubulin inhibitor that arrests tumor cell growth at the G2/M phase. Its binding site… 
2007
2007
Phase I and pharmacological study of orally administered indibulin in advanced solid tumors
2565 Background: Indibulin (ZIO-301/D-24851) (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid) a novel, oral… 
2007
2007
Translation of indibulin (ZIO-301) preclinical antiangiogenic and antimetastatic activity to the clinic
B283 Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally… 
2006
2006
Oral solid pharmaceutical formulation of Indibulin tribulininhibitoren
2006
2006
Solid oral dosage form of the tribulinhemmstoffs Indibulin