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indibulin

Known as: N-(Pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glycoxylamide, N-(pyridin-4-yl)-(1-(4-chlorobenzyl)indol-3-yl)glyoxylamide 
A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from… 
National Institutes of Health

Related topics

Related topics

5 relations

Broader (2)

AcetamidesIndoles

Narrower (1)

D 24851
Microtubule ProcessNCIt Antineoplastic Agent Terminology

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Design, Synthesis and in vitro Anti-Cancer evaluation of Novel Derivatives of 2-(2-Methyl-1,5-diaryl-1H-pyrrol-3-yl)-2-oxo-N-(pyridin-3-yl)acetamide.
OBJECTIVE Several anti-tubulin agents were introduced for the cancer treatment so far. Despite successes in the treatment of… 
2016
2016
Evaluation of indibulin, a novel tubulin targeting-agent, in combination with capecitabine, with mathematically optimized dose scheduling.
2538 Background: Indibulin (IDB) is a novel, orally available tubulin-targeting molecule that perturbs cancer cell migration and… 
2012
2012
Abstract P6-11-10: IBL2001: Phase I/II study of a novel dose-dense schedule of oral indibulin for the treatment of metastastic breast cancer.
Background: Indibulin (ZI0-301) is a novel, oral, synthetic small molecule microtubule inhibitor which binds tubulin at a… 
2012
2012
[Molecular dynamics simulation of the tubulin dimer with cytostatics].
Colchicin, podophylotoxin and indibulin are natural cytostatics that are used in the treatment of neoplasms. But applications of… 
Highly Cited
2009
Highly Cited
2009
Indibulin, a novel microtubule inhibitor, discriminates between mature neuronal and nonneuronal tubulin.
Microtubule inhibitors interfere with microtubule dynamics, causing cell cycle arrest and apoptosis. These effects are… 
2008
2008
A novel oral tubulin inhibitor: Safety and preliminary efficacy of two Phase I studies with indibulin
B4 Purpose: Indibulin is a novel oral tubulin inhibitor that arrests tumor cell growth at the G2/M phase. Its binding site… 
2007
2007
Phase I dose-finding and pharmacokinetic trial of orally administered indibulin (D-24851) to patients with solid tumors
SummaryIndibulin is a synthetic small molecule which antitumor activity is based upon destabilization of microtubules. The… 
2007
2007
Phase I and pharmacological study of orally administered indibulin in advanced solid tumors
2565 Background: Indibulin (ZIO-301/D-24851) (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid) a novel, oral… 
2007
2007
Indibulin (ZIO-301): An orally active tubulin polymerization inhibitor with a unique molecular mechanism of action
B276 Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally… 
2007
2007
Translation of indibulin (ZIO-301) preclinical antiangiogenic and antimetastatic activity to the clinic
B283 Indibulin (N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid; ZIO-301 or D-24851) is a novel synthetic, orally… 
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