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imidaprilat

Known as: 3-(2-(N-(1-carboxy-3-phenylpropyl)amino)propionyl)-1-methyl-2-oxoimidazolidine-4-carboxylic acid 
An angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Imidaprilat competitively binds to and inhibits ACE, thereby… 
National Institutes of Health

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6366A

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Imidazolidines

Papers overview

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2008
2008
Allosteric kinetics of human carboxylesterase 1: species differences and interindividual variability.
Esterified drugs such as imidapril, derapril, and oxybutynin hydrolyzed by carboxylesterase 1 (CES1) are extensively used in… 
2007
2007
Angiotensin-Converting Enzyme Inhibitor Attenuates Monocyte Adhesion to Vascular Endothelium through Modulation of Intracellular Zinc
To elucidate an anti-inflammatory role of angiotensin-converting enzyme inhibitors (ACEIs) in cardiovascular disease, we studied… 
2000
2000
Protective Effects of Imidapril on He-Ne Laser-Induced Thrombosis in Cerebral Blood Vessels of Stroke-Prone Spontaneously Hypertensive Rats
Summary Inhibitors of angiotensin converting enzyme (ACE) have been developed recently for therapeutic purposes in hypertension… 
1999
1999
Expression, secretion, and inhibition of angiotensin-converting enzyme in cultured human bronchial epithelial cells.
1999
1999
Determination of imidapril and imidaprilat in human plasma by high-performance liquid chromatography-electrospray ionization tandem mass spectrometry.
1997
1997
Role of kinin and renal ANG II blockade in acute effects of ACE inhibitors in low-renin hypertension.
In conscious deoxycorticosterone acetate (DOCA) salt-hypertensive dogs, the angiotensin-converting enzyme (ACE) inhibitors… 
1997
1997
Pharmacokinetics and pharmacodynamics of a sustained-release biodegradable pellet containing imidapril, a new angiotensin-converting enzyme inhibitor in spontaneously hypertensive rats.
1996
1996
Studies on the Magnitude and the Mechanism of Cough Potentiation by Angiotensin‐Converting Enzyme Inhibitors in Guinea‐pigs: Involvement of Bradykinin in the Potentiation
One adverse effect of the angiotensin‐converting enzyme (ACE) inhibitors used for treatment of hypertension and congestive heart… 
1995
1995
A saturable tissue-angiotensin I converting enzyme (ACE) binding model for the pharmacokinetic analysis of imidapril, a new ACE inhibitor, and its active metabolite in human.
In order to obtain a rational explanation and analytical method of the unique pharmacokinetic behaviors of imidapril and… 
1994
1994
Differential Inhibition of Bradykinin Hydrolysis by Four ACE Inhibitors: a Possible Explanation for Differences in Induced Coughing
Coughing is an adverse reaction to angiotensin-converting enzyme (ACE) inhibitors, but some ACE inhibitors cause more coughing… 
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