illudin T
National Institutes of Health
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Acylfulvenes are a class of antitumor agents derived from illudin S, a sesquiterpenoid toxin isolated from mushrooms of the genus…
The unfavorable therapeutic index of the fungal cytotoxin illudin M was to be improved by covalent attachment of the redox…
14082 Background: IROF, a semisynthetic derivative of the natural product illudin S, is a novel DNA binding agent that has…
2042 Background: Irofulven (IROF), a semisynthetic derivative of the natural product illudin S, is a novel DNA binding agent that…
MGI 114, an analog of illudin S, shows potent activity against a broad range of human tumors in vitro and in vivo, including drug…
MGI 114 (6-hydroxymethylacylfulvene, HMAF) is a novel semisynthetic antitumor compound derived from the sesquiterpene mushroom…
Six first-generation illudin analogs were tested for antitumor activity using in vitro cytotoxicity and in vivo xenograft models…