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hydroxyebastine

 
National Institutes of Health

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2018
2018
17α-Ethynylestradiol (EE), a major component of many oral contraceptives, affects the activities of a number of the human… Expand
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2018
2018
Cytochrome P450 2J2 (CYP2J2) is involved in the metabolism of drugs, including albendazole, astemizole, ebastine, and endogenous… Expand
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2017
2017
The mechanism-based inactivation of human CYP2J2 by three terminal acetylenic compounds: N-(methylsulfonyl)-6-(2… Expand
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2015
2015
Cytochrome P450 2J2 (CYP2J2) is an enzyme responsible for the metabolism of endogenous substrates including arachidonic acid, as… Expand
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2011
2011
Although selective inhibitors of cytochrome P450 enzymes can be used to determine relative contributions of the enzymes to… Expand
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2011
2011
A practical synthesis of hydroxyebastine,the primary active metabolite of a new antianaphylaxis drug ebastine,was fully described… Expand
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Highly Cited
2006
Highly Cited
2006
Ebastine undergoes extensive metabolism to form desalkylebastine and hydroxyebastine. Hydroxyebastine is subsequently metabolized… Expand
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2004
2004
We developed a method for determining ebastine, a new generation of antihistamines, and its three metabolites (hydroxyebastine… Expand
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2001
2001
Ebastine (CAS 90729-43-4) is an antiallergic agent which selectively and potently blocks histamine H1-receptors in vivo. A simple… Expand
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1998
1998
Ebastine [4'-tert-butyl-4-[4-(diphenylmethoxy)piperidino]butyro phe- none] is a new-generation, nonsedative, H1 antihistamine… Expand
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