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hepatocyte dedifferentiation

The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Maintenance of Primary Hepatocyte Functions In Vitro by Inhibiting Mechanical Tension-Induced YAP Activation.
2017
2017
Physiological oxygen tension reduces hepatocyte dedifferentiation in in vitro culture
Primary hepatocytes cultured in vitro are a powerful tool to study the functions of hepatocytes and to evaluate the metabolism… 
2015
2015
Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.
Ectopic expression of Pdx1 triggers rapid hepatocyte dedifferentiation by down-regulating liver-enriched transcription factors… 
2015
2015
Abstract 4982: Increased core fucosylation, a glycan alteration associated with cancer, is the result of hepatocyte dedifferentiation
Alterations in N-linked glycosylation have been associated with the development of cancer. One such modification, core… 
2014
2014
Hepatocyte-ductal transdifferentiation is mediated by reciprocal repression of SOX9 and C/EBPα.
Primary hepatocytes rapidly dedifferentiate when cultured in vitro. We have studied the mechanism of hepatocyte dedifferentiation… 
2013
2013
Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
BackgroundDedifferentiation and loss of hepatocyte polarity during primary culture of hepatocytes are major drawbacks for… 
2013
2013
Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
Dedifferentiation and loss of hepatocyte polarity during primary culture of hepatocytes are major drawbacks for metabolic… 
Highly Cited
2008
Highly Cited
2008
Genomics and proteomics analysis of cultured primary rat hepatocytes.
Review
2004
Review
2004
Hepatic oval cells: helping redefine a paradigm in stem cell biology.
Highly Cited
1998
Highly Cited
1998
Liver regeneration and alpha-fetoprotein messenger RNA expression in the retrorsine model for hepatocyte transplantation.
Recently, we described a new model for hepatocyte transplantation with nearly total replacement of the liver by exogenous… 
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