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hepatocyte dedifferentiation

The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the… 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Implication of hepatocyte dedifferentiation in pathogenesis and treatment of hepatocellular carcinoma
Liver cancer is the fifth most common malignancy worldwide and the third most common cause of cancer-related death. Five hundred… 
2018
2018
[Analysis of transcriptional factors expression profile during dedifferentiation of liver cell cultured in vitro].
Primary hepatocytes are widely used in drug metabolism and toxicity assessment. As the culture of primary hepatocytes in vitro is… 
2015
2015
Pancreatic and duodenal homeobox gene 1 (Pdx1) down-regulates hepatic transcription factor 1 alpha (HNF1α) expression during reprogramming of human hepatic cells into insulin-producing cells.
Ectopic expression of Pdx1 triggers rapid hepatocyte dedifferentiation by down-regulating liver-enriched transcription factors… 
2015
2015
Abstract 4982: Increased core fucosylation, a glycan alteration associated with cancer, is the result of hepatocyte dedifferentiation
Alterations in N-linked glycosylation have been associated with the development of cancer. One such modification, core… 
2013
2013
Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
BackgroundDedifferentiation and loss of hepatocyte polarity during primary culture of hepatocytes are major drawbacks for… 
2013
2013
Distinct dedifferentiation processes affect caveolin-1 expression in hepatocytes
Dedifferentiation and loss of hepatocyte polarity during primary culture of hepatocytes are major drawbacks for metabolic… 
2013
2013
ANALYSIS OF THE CELL-ADHESION SIGNALING NETWORK AND ITS CROSSTALK WITH THE EPIDERMAL GROWTH FACTOR PATHWAY IN PRIMARY RAT HEPATOCYTES
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2006
2006
Contribution of non-parenchymal cells to the performance of micropatterned hepatocytes.
Hepatocytes within current bioartificial liver designs are unable to maintain the wide range of differentiated functions observed… 
1995
1995
Effects of hepatocyte growth factor on viability and biotransformation functions of hepatocytes in gel entrapped and monolayer culture.
OBJECTIVES An extracorporeal bioartificial liver device must maintain viability and differentiated function of hepatocytes… 
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