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heparin-binding EGF-like growth factor

Known as: Heparin-binding EGF-like Growth-Factor, Heparin binding EGF like Growth Factor, HB-EGF 
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as… Expand
National Institutes of Health

Related topics

Related topics

12 relations
HBEGF geneHBEGF wt AlleleIn BloodProcess of secretion
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Narrower (3)

HBEGF protein, humanShort Form HB-EGFdiphtheria toxin receptor

Papers overview

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Highly Cited
2007
Highly Cited
2007
Juxtacrine Activation of Epidermal Growth Factor (EGF) Receptor by Membrane-anchored Heparin-binding EGF-like Growth Factor Protects Epithelial Cells from Anoikis While Maintaining an Epithelial…
Loss of cell-matrix adhesion is often associated with acute epithelial injury, suggesting that “anoikis” may be an important… Expand
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Highly Cited
2005
Highly Cited
2005
Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner*
Adiponectin, an adipocyte-specific secretory protein, is present in serum as three oligomeric complexes. Apart from its roles as… Expand
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Highly Cited
2004
Highly Cited
2004
Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Cytotrophoblasts of the anchoring villi convert during human placentation from a transporting epithelium to an invasive… Expand
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Highly Cited
2001
Highly Cited
2001
N‐arginine dibasic convertase is a specific receptor for heparin‐binding EGF‐like growth factor that mediates cell migration
Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF), a mitogen and chemotactic factor, binds to two receptor… Expand
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Highly Cited
1999
Highly Cited
1999
Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor*
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) transduces mitogenic signals through the EGF receptor (EGFR… Expand
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1999
1999
Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction.
Heparin-binding epidermal growth factor-like growth factor (HB-EGF), an activating ligand for the epidermal growth factor… Expand
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Highly Cited
1998
Highly Cited
1998
Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells.
Cultured rat bladder smooth muscle cells (SMC) were grown on collagen-coated silicone membranes and subjected to continuous… Expand
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Highly Cited
1997
Highly Cited
1997
The Membrane-bound Form of Heparin-binding Epidermal Growth Factor-like Growth Factor Promotes Survival of Cultured Renal Epithelial Cells*
To understand whether expression of membrane-anchored heparin binding epidermal growth factor (proHB-EGF) is involved in renal… Expand
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Highly Cited
1995
Highly Cited
1995
Rapid induction of heparin-binding epidermal growth factor/diphtheria toxin receptor expression by Raf and Ras oncogenes.
We have used differential display PCR to search for mRNAs induced by delta Raf-1:ER, an estradiol-dependent form of Raf-1 kinase… Expand
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Highly Cited
1979
Highly Cited
1979
Isolation of the human placenta receptor for epidermal growth factor-urogastrone
EPIDERMAL growth factor-urogastrone (EGF-URO), a singlechain polypeptide of molecular weight ∼6,000, found both in the mouse1–3… Expand
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