heparin-binding EGF-like growth factor

Known as: Heparin-binding EGF-like Growth-Factor, Heparin binding EGF like Growth Factor, HB-EGF 
An EGF family member that is expressed in a variety of hematopoietic, endothelial, vascular smooth muscle, and epithelial cells. It is synthesized as… (More)
National Institutes of Health

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HBEGF geneHBEGF wt AlleleIn BloodProcess of secretion
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HBEGF protein, humanShort Form HB-EGFdiphtheria toxin receptor

Papers overview

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2012
2012
Soluble heparin-binding EGF-like growth factor (HB-EGF) detected by newly developed immuno-PCR method is a clear-cut serological biomarker for ovarian cancer.
Heparin-binding EGF-like growth factor (HB-EGF) is a member of the EGF family of growth factors that bind to and activate the EGF… (More)
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2009
2009
Heparin-binding EGF-like growth factor is a potent dilator of terminal mesenteric arterioles.
OBJECTIVE We have previously shown that heparin-binding EGF-like growth factor (HB-EGF) protects the intestines from multiple… (More)
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2007
2007
Juxtacrine activation of epidermal growth factor (EGF) receptor by membrane-anchored heparin-binding EGF-like growth factor protects epithelial cells from anoikis while maintaining an epithelial…
Loss of cell-matrix adhesion is often associated with acute epithelial injury, suggesting that "anoikis" may be an important… (More)
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Highly Cited
2005
Highly Cited
2005
Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner.
Adiponectin, an adipocyte-specific secretory protein, is present in serum as three oligomeric complexes. Apart from its roles as… (More)
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Highly Cited
2004
Highly Cited
2004
Heparin-binding EGF-like growth factor regulates human extravillous cytotrophoblast development during conversion to the invasive phenotype.
Cytotrophoblasts of the anchoring villi convert during human placentation from a transporting epithelium to an invasive… (More)
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2001
2001
N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor that mediates cell migration.
Heparin-binding epidermal growth factor-like growth factor (HB-EGF), a mitogen and chemotactic factor, binds to two receptor… (More)
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1999
1999
Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor.
Heparin-binding epidermal growth factor-like growth factor (HB-EGF) transduces mitogenic signals through the EGF receptor (EGFR… (More)
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1999
1999
Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction.
Heparin-binding epidermal growth factor-like growth factor (HB-EGF), an activating ligand for the epidermal growth factor… (More)
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1998
1998
Stretch activates heparin-binding EGF-like growth factor expression in bladder smooth muscle cells.
Cultured rat bladder smooth muscle cells (SMC) were grown on collagen-coated silicone membranes and subjected to continuous… (More)
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1997
1997
The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells.
To understand whether expression of membrane-anchored heparin binding epidermal growth factor (proHB-EGF) is involved in renal… (More)
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