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hemoglobin catabolic process

Known as: haemoglobin catabolism, hemoglobin catabolism, hemoglobin degradation 
The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1955-2018
051019552017

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haemoglobin hydrolysis

Related mentions per year

Related mentions per year

1956-2018
1960198020002020
hemoglobin catabolic process
haemoglobin hydrolysis

Papers overview

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2008
2008
Plasmodium food vacuole plasmepsins are activated by falcipains.
Intraerythrocytic malaria parasites use host hemoglobin as a major nutrient source. Aspartic proteases (plasmepsins) and cysteine… (More)
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Highly Cited
2003
Highly Cited
2003
Data-mining approaches reveal hidden families of proteases in the genome of malaria parasite.
The search for novel antimalarial drug targets is urgent due to the growing resistance of Plasmodium falciparum parasites to… (More)
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Highly Cited
2002
Highly Cited
2002
Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products.
OBJECT The mechanisms involved in brain edema formation following intracerebral hemorrhage (ICH) have not been fully elucidated… (More)
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Highly Cited
2002
Highly Cited
2002
Four plasmepsins are active in the Plasmodium falciparum food vacuole, including a protease with an active-site histidine.
Hemoglobin degradation is a metabolic process that is central to the growth and maturation of the malaria parasite Plasmodium… (More)
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Highly Cited
2002
Highly Cited
2002
A role for the protease falcipain 1 in host cell invasion by the human malaria parasite.
Cysteine proteases of Plasmodium falciparum are required for survival of the malaria parasite, yet their specific cellular… (More)
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Highly Cited
2000
Highly Cited
2000
Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum.
Trophozoites of the malaria parasite Plasmodium falciparum hydrolyze erythrocyte hemoglobin in an acidic food vacuole to provide… (More)
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Highly Cited
1999
Highly Cited
1999
Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite.
Endoperoxide antimalarials based on the ancient Chinese drug Qinghaosu (artemisinin) are currently our major hope in the fight… (More)
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1991
1991
Hemoglobin degradation in the human malaria pathogen Plasmodium falciparum: a catabolic pathway initiated by a specific aspartic protease
Hemoglobin is an important nutrient source for intraerythrocytic malaria organisms. Its catabolism occurs in an acidic digestive… (More)
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Highly Cited
1989
Highly Cited
1989
Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite.
We have shown that UVA (320-380 nm) radiation, hydrogen peroxide, and sodium arsenite induce a stress protein of approximately 32… (More)
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Highly Cited
1988
Highly Cited
1988
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
To obtain free amino acids for protein synthesis, trophozoite stage malaria parasites feed on the cytoplasm of host erythrocytes… (More)
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