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hellebrin

Known as: 3,5,14-Trihydroxy-19-oxobufa-20,22-dienolide, corelborin, corelborine 
National Institutes of Health

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Related topics

1 relation

Broader (1)

Bufanolides

Papers overview

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2020
2020
Antiseizure potential of the ancient Greek medicinal plant Helleborus odorus subsp. cyclophyllus and identification of its main active principles.
2013
2013
Structure-activity relationship analysis of bufadienolide-induced in vitro growth inhibitory effects on mouse and human cancer cells.
The in vitro growth inhibitory effects of 27 bufadienolides and eight degradation products, with two cardenolides (ouabain and… 
2012
2012
Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase
BackgroundSurface-expressed Na+/K+-ATPase (NaK) has been suggested to function as a non-canonical cardiotonic steroid-binding… 
2012
2012
Cytotoxic activity of some glycoconjugates including saponins and anthracyclines.
2011
2011
An approach to the synthesis and attachment of scillabiose to steroids
2010
2010
FTIR spectral signature of the effect of cardiotonic steroids with antitumoral properties on a prostate cancer cell line.
2010
2010
Rapid structural identification of cytotoxic bufadienolide sulfates in toad venom from Bufo melanosticus by LC-DAD-MS(n) and LC-SPE-NMR.
Toad venom, namely, "Chansu" in China, has been widely used for the treatment of heart failure, sores, pains, and various cancers… 
2008
2008
Anti-cancer natural product library from traditional chinese medicine.
The cure rates in cancer chemotherapy are affected by the development of drug resistance and severe side effects. Due to these… 
Highly Cited
2003
Highly Cited
2003
Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives.
1975
1975
Variant HeLa cells selected for their resistance to ouabain
The cardiac glycoside, ouabain, normally kills HeLa cells at concentrations of about 10−7 m or greater. By treating a population… 
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