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Background Myocardial infarction (MI) due to coronary artery disease remains one of the leading causes of premature death… Expand The TGFbeta family member Nodal has been implicated in heart induction through misexpression of a dominant negative version of… Expand Abstract: We have characterized two signaling pathways that induce heart tissue during embryonic development. The first is… Expand Inhibition of canonical Wnt/beta-catenin signaling by Dickkopf-1 (Dkk-1) or Crescent initiates cardiogenesis in vertebrate… Expand Amphibian embryos are an excellent model system for analyzing the mechanisms of vertebrate cardiogenesis. Studies of heart… Expand Abstract— The heart is the first organ to form during embryogenesis and its circulatory function is critical from early on for… Expand BACKGROUND
The mouse anterior visceral endoderm, an extraembryonic tissue, expresses several genes essential for normal… Expand The genetic pathways underlying the induction and anterior-posterior patterning of the heart are poorly understood. The recent… Expand Heart induction in Xenopus has been thought to be dependent primarily on the interaction of the heart primordia with the Spemann… Expand Homozygosity for simple recessive gene c in axolotl embryos results in the absence of a heartbeat. Gene c alters the morphology… Expand