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guanidinohydantoin

National Institutes of Health

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GuanidinesHydantoins

Papers overview

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2011
2011
Comparison of Transition Metal-Mediated Oxidation Reactions of Guanine in Nucleoside and Single-Stranded Oligodeoxynucleotide Contexts.
2010
2010
Copper generated reactive oxygen leads to formation of lysine-DNA adducts.
2009
2009
Mechanistic aspects of the formation of guanidinohydantoin from spiroiminodihydantoin under acidic conditions.
Experimentally, it was observed that the oxidized guanine lesion spiroiminodihydantoin (Sp) contained in highly purified… 
2007
2007
Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus.
2007
2007
Mechanisms of DNA damage and insight into mutations by chromium(VI) in the presence of glutathione.
2005
2005
Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells.
2005
2005
Oxidised guanidinohydantoin (Ghox) and spiroiminodihydantoin (Sp) are major products of iron- and copper-mediated 8-oxo-7,8-dihydroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation.
8-Oxo-7,8-dihydroguanine (8-oxoGua), an important biomarker of DNA damage in oxidatively generated stress, is highly reactive… 
2003
2003
Effect of the oxidized guanosine lesions spiroiminodihydantoin and guanidinohydantoin on proofreading by Escherichia coli DNA polymerase I (Klenow fragment) in different sequence contexts.
Oxidative damage to DNA by endogenous and exogenous reactive oxygen species has been directly linked to cancer, aging, and a… 
2002
2002
DNA oxidation by peroxo-chromium(v) species: oxidation of guanosine to guanidinohydantoin.
Reactions of peroxo-chromium(v) complexes with DNA afforded mainly guanine oxidation yielding, a four-electron oxidation product… 
Highly Cited
2000
Highly Cited
2000
Removal of hydantoin products of 8-oxoguanine oxidation by the Escherichia coli DNA repair enzyme, FPG.
An intriguing feature of 7,8-dihydro-8-oxo-2'-deoxyguanosine (OG) is that it is highly reactive toward further oxidation. Indeed… 
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