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guanadrel
Known as:
(1,4-dioxaspiro(4.5)dec-2-ylmethyl)guanidine
, Guanadrelum
, guanadrel [Chemical/Ingredient]
National Institutes of Health
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Related topics
Related topics
7 relations
Broader (2)
Antihypertensive Agents
Guanidines
Decreased Blood Pressure [PE]
Drug Allergy
Guanadrel sulfate
Hypertensive disease
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2012
2012
Guanadrel
Dr F. A. Finnerty
,
R. N. Brogden
Drugs
2012
Corpus ID: 264006399
SummarySynopsis: Guanadrel1 sulphate is an orally active peripheral sympathetic inhibitor (adrenergic neuron-blocking drug). In…
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2001
2001
N-hydroxyl derivatives of guanidine based drugs as enzymatic NO donors.
M. Xian
,
Xiaopeng Li
,
+5 authors
P. Wang
Bioorganic & Medicinal Chemistry Letters
2001
Corpus ID: 28729534
1989
1989
Disposition of Guanadrel in Subjects with Normal and Impaired Renal Function
C. Halstenson
,
J. Opsahl
,
+4 authors
G. Matzke
Journal of clinical pharmacology
1989
Corpus ID: 39500951
The disposition of a single 25 mg oral dose of guanadrel was evaluated in 22 subjects with various degrees of renal function. The…
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1985
1985
Pharmacologic reduction of sympathetic drive increases platelet alpha‐2–receptor number
B. Egan
,
R. Neubig
,
S. Julius
Clinical pharmacology and therapy
1985
Corpus ID: 41463000
Several lines of evidence implicate sympathetic nervous system involvement in the pathophysiology of essential hypertension in…
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1983
1983
Guanadrel Sulfate: A Postganglionic Sympathetic Inhibitor for the Treatment of Mild to Moderate Hypertension
J. Palmer
,
C. A. Nugent
Pharmacotherapy
1983
Corpus ID: 7113767
Guanadrel sulfate is structurally and pharmacologically similar to guanethidine but has different pharmacokinetic properties. The…
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1983
1983
Comparison of guanadrel and guanethidine efficacy and side effects.
Malinow Sh
1983
Corpus ID: 76945924
: Eighteen patients with essential hypertension uncontrolled by hydrochlorothiazide alone were randomly assigned to receive…
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1983
1983
Safety and efficacy of a three-drug regimen for the treatment of hypertension: hydrochlorothiazide, propranolol, and guanadrel.
R. Gore
Clinical Therapeutics
1983
Corpus ID: 36516660
Twenty-seven patients with moderate to moderately severe hypertension who had not responded optimally to treatment with a…
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1973
1973
Comparison of guanadrel and guanethidine
L. Hansson
,
A. Pascual
,
S. Julius
Clinical pharmacology and therapy
1973
Corpus ID: 7154497
Both guanadrel and guanethidine caused a statistically significant reduction of blood pressure when compared to placebo, but…
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1972
1972
Cardiovascular Profile of the Antihypertensive Agent, Guanadrel
T. Pruss
,
J. Hidalgo
Proceedings of the Society for Experimental…
1972
Corpus ID: 19378522
Summary Guanadrel was evaluated for its cardiovascular profile and was found to possess properties which are desirable in the…
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1972
1972
Short term effectiveness and hemodynamic actions of guanadrel, a new sympatholytic drug.
A. Pascual
,
S. Julius
Current Therapeutic Research
1972
Corpus ID: 42961791
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