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glycoprotein 41

Known as: GP 41, GP-41 
National Institutes of Health

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Broader (1)

Membrane Glycoproteins

Papers overview

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2017
2017
A novel HIV-1 gp41 tripartite model for rational design of HIV-1 fusion inhibitors with improved antiviral activity
Objectives: During HIV-1 fusion process, the N-terminal heptad repeat (NHR) of the HIV-1 glycoprotein 41 (gp41) interacts with… 
2015
2015
Kinetically coupled folding of a single HIV-1 glycoprotein 41 complex in viral membrane fusion and inhibition
Significance Enveloped viruses infect cells via fusion of viral and host cell membranes mediated by highly conserved fusion… 
2012
2012
A gp41-based heteroduplex mobility assay provides rapid and accurate assessment of intrasubtype epidemiological linkage in HIV type 1 heterosexual transmission Pairs.
A critical step in HIV-1 transmission studies is the rapid and accurate identification of epidemiologically linked transmission… 
Review
2012
Review
2012
Computer-Aided Approaches for Targeting HIVgp41
Virus-cell fusion is the primary means by which the human immunodeficiency virus-1 (HIV) delivers its genetic material into the… 
Review
2011
Review
2011
Insights into the mechanism of HIV-1 envelope induced membrane fusion as revealed by its inhibitory peptides
HIV-1 fusion with its target cells is mediated by the glycoprotein 41 (gp41) transmembrane subunit of the viral envelope… 
2010
2010
Interfacial properties and structure stability of the gp41 tryptophan-rich peptide from HIV-1.
2005
2005
Heptad-Repeat-2 Mutations Enhance the Stability of the Enfuvirtide-Resistant HIV-1 gp41 Hairpin Structure
Enfuvirtide (T20) is a peptide-based fusion inhibitor derived from the heptad repeat 2 (HR2) region of HIV-1 glycoprotein 41… 
1995
1995
Induction of IL-6 and IL-10 production by recombinant HIV-1 envelope glycoprotein 41 (gp41) in the THP-1 human monocytic cell line.
Elevated levels of circulating monokines (IL-6, IL-1, and TNF alpha) have been seen in HIV-1 infection, and the overproduction of… 
1992
1992
Bispecific antibody targeting of human immunodeficiency virus type 1 (HIV-1) glycoprotein 41 to human macrophages through the Fc IgG receptor I mediates neutralizing effects in HIV-1 infection.
Human monocyte-derived macrophages that express the CD4 molecule and the Fc receptor for IgG (Fc gamma R) play a major role in… 
1991
1991
Functional Epitope Analysis of the Human CD 11 a/CD 18 Molecule (LFA‐1, Lymphocyte Function‐Associated Antigen 1) Involved in HIV‐1‐Induced Syncytium Formation
After binding lo the CD4 receptor, the human Immunodeficiency virus I HIV‐I)may enter the T cell and induce the formation of… 
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