• Publications
  • Influence
Mechanism of the binding, insertion and destabilization of phospholipid bilayer membranes by alpha-helical antimicrobial and cell non-selective membrane-lytic peptides.
  • Y. Shai
  • Medicine, Chemistry
  • Biochimica et biophysica acta
  • 15 December 1999
Permeation of the cell membrane leading to cell death is a mechanism used by a large number of membrane-lytic peptides. Some are linear, mostly helical, and others contain one or more disulfide bondsExpand
  • 1,552
  • 42
Mode of action of membrane active antimicrobial peptides.
  • Y. Shai
  • Medicine, Chemistry
  • Biopolymers
  • 2002
Water-membrane soluble protein and peptide toxins are used in the defense and offense systems of all organisms, including plants and humans. A major group includes antimicrobial peptides, which serveExpand
  • 1,188
  • 40
Structure and organization of the human antimicrobial peptide LL-37 in phospholipid membranes: relevance to the molecular basis for its non-cell-selective activity.
The antimicrobial peptide LL-37 belongs to the cathelicidin family and is the first amphipathic alpha-helical peptide isolated from human. LL-37 is considered to play an important role in the firstExpand
  • 453
  • 27
Endotoxin (Lipopolysaccharide) Neutralization by Innate Immunity Host-Defense Peptides
Binding of lipopolysaccharide (LPS) to macrophages results in proinflammatory cytokine secretion. In extreme cases it leads to endotoxic shock. A few innate immunity antimicrobial peptides (AMPs)Expand
  • 325
  • 19
Mode of action of linear amphipathic alpha-helical antimicrobial peptides.
The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides seem to be aExpand
  • 249
  • 19
Ultrashort antibacterial and antifungal lipopeptides
Host-defense cationic antimicrobial peptides (≈12–50 aa long) play an essential protective role in the innate immune system of all organisms. Lipopeptides, however, are produced only in bacteria andExpand
  • 313
  • 16
Mode of action of linear amphipathic α-helical antimicrobial peptides
The increasing resistance of bacteria to conventional antibiotics resulted in a strong effort to develop antimicrobial compounds with new mechanisms of action. Antimicrobial peptides seem to be aExpand
  • 613
  • 15
Interaction of antimicrobial dermaseptin and its fluorescently labeled analogues with phospholipid membranes.
Dermaseptin, a 34 amino-acid residue antimicrobial polypeptide [Mor, A., Nguyen, V. H., Delfour, A., Migliore-Samour, D., & Nicolas, P. (1991) Biochemistry 30, 8824-8830] was synthesized andExpand
  • 516
  • 11
Host defense peptides as new weapons in cancer treatment
  • N. Papo, Y. Shai
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 1 April 2005
Abstract.In the last decade intensive research has been conducted to determine the role of innate immunity host defense peptides (also termed antimicrobial peptides) in the killing of prokaryotic andExpand
  • 384
  • 10
From “carpet” mechanism to de-novo designed diastereomeric cell-selective antimicrobial peptides
Living organisms of all types produce a large repertoire of gene-encoded, net positively charged, antimicrobial peptides as part of their innate immunity to microbial invasion. Despite significantExpand
  • 277
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