FAQ

glutathione catabolic process

Known as: glutathione breakdown, glutathione catabolism, glutathione degradation 
The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1956-2017
024619562016

Papers overview

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2012
2012
Mammalian proapoptotic factor ChaC1 and its homologues function as γ-glutamyl cyclotransferases acting specifically on glutathione.
ChaC1 is a mammalian proapoptic protein of unknown function induced during endoplasmic reticulum stress. We show using in vivo… (More)
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2012
2012
Glutathione degradation by the alternative pathway (DUG pathway) in Saccharomyces cerevisiae is initiated by (Dug2p-Dug3p)2 complex, a novel glutamine amidotransferase (GATase) enzyme acting on…
The recently identified, fungi-specific alternative pathway of glutathione degradation requires the participation of three genes… (More)
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2011
2011
Gastric epithelial cell death caused by Helicobacter suis and Helicobacter pylori γ-glutamyl transpeptidase is mainly glutathione degradation-dependent.
Helicobacter (H.) suis is the most prevalent non-H. pylori Helicobacter species colonizing the stomach of humans suffering from… (More)
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2011
2011
Glutathione biosynthesis in the yeast pathogens Candida glabrata and Candida albicans: essential in C. glabrata, and essential for virulence in C. albicans.
Redox pathways play a key role in pathogenesis. Glutathione, a central molecule in redox homeostasis in yeasts, is an essential… (More)
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2009
2009
The association of plasma cysteine and gamma-glutamyltransferase with BMI and obesity.
We recently reported a strong positive association of plasma total cysteine (tCys) with fat mass in over 5,000 subjects. As gamma… (More)
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2008
2008
A gamma-glutamyl transpeptidase-independent pathway of glutathione catabolism to glutamate via 5-oxoproline in Arabidopsis.
The degradation pathway of glutathione (GSH) in plants is not well understood. In mammals, GSH is predominantly metabolized… (More)
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2007
2007
The alternative pathway of glutathione degradation is mediated by a novel protein complex involving three new genes in Saccharomyces cerevisiae.
Glutathione (GSH), L-gamma-glutamyl-L-cysteinyl-glycine, is the major low-molecular-weight thiol compound present in almost all… (More)
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2003
2003
Utilization of glutathione as an exogenous sulfur source is independent of gamma-glutamyl transpeptidase in the yeast Saccharomyces cerevisiae: evidence for an alternative gluathione degradation…
gamma-Glutamyl transpeptidase (gamma-GT) is the only enzyme known to be responsible for glutathione degradation in living cells… (More)
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Highly Cited
1999
Highly Cited
1999
Tissue engineering of a bioartificial renal tubule assist device: in vitro transport and metabolic characteristics.
BACKGROUND Current renal substitution therapy for acute or chronic renal failure with hemodialysis or hemofiltration is life… (More)
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1985
1985
Conjugation of acetaldehyde with cysteinylglycine, the first metabolite in glutathione breakdown byγ-glutamyltranspeptidase
Glutathione and its metabolites were examined for reactivity to acetaldehyde. When acetaldehyde was incubated with glutathione… (More)
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