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glutaryl-7-aminocephalosporanic acid

Known as: Gl-7-ACA, glutaryl-7-ACA 
 
National Institutes of Health

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1 relation

Broader (1)

Cephalosporins

Papers overview

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Highly Cited
2008
Highly Cited
2008
Optimization of glutaryl-7-aminocephalosporanic acid acylase expression in E. coli.
A recombinant glutaryl-7-aminocephalosporanic acid acylase (GLA) from Pseudomonas N176 has been over-expressed in BL21(DE3)pLysS… Expand
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2003
2003
Analysis of a substrate specificity switch residue of cephalosporin acylase.
Residue Phe375 of cephalosporin acylase has been identified as one of the residues that is involved in substrate specificity. A… Expand
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Highly Cited
2002
Highly Cited
2002
Altering the Substrate Specificity of Cephalosporin Acylase by Directed Evolution of the β-Subunit*
Using directed evolution, we have selected an adipyl acylase enzyme that can be used for a one-step bioconversion of adipyl-7… Expand
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Highly Cited
2001
Highly Cited
2001
Structure of cephalosporin acylase in complex with glutaryl-7-aminocephalosporanic acid and glutarate: insight into the basis of its substrate specificity.
  • Y Kim, W. Hol
  • Chemistry & biology
  • 2001
    • Corpus ID: 11249334
BACKGROUND Semisynthetic cephalosporins are primarily synthesized from 7-aminocephalosporanic acid (7-ACA), which is obtained by… Expand
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2000
2000
Characterization of an industrial biocatalyst: immobilized glutaryl-7-ACA acylase.
A batch of the immobilized industrial biocatalyst glutaryl-7-ACA acylase (GA), one of the two enzymes involved in the… Expand
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1998
1998
Two-step autocatalytic processing of the glutaryl 7-aminocephalosporanic acid acylase from Pseudomonas sp. strain GK16.
The glutaryl-7-aminocephalosporanic acid (GL-7-ACA) acylase of Pseudomonas sp. strain GK16 is an (alphabeta)2 heterotetramer of… Expand
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Highly Cited
1995
Highly Cited
1995
Two‐step immobilized enzyme conversion of cephalosporin C to 7‐aminocephalosporanic acid
The first large‐scale production of 7‐aminocephalosporanic acid (7ACA) from cephalosporin C (CPC) using a wholly enzymatic… Expand
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1994
1994
Biochemical characterization of a glutaryl-7-aminocephalosporanic acid acylase from Pseudomonas strain BL072.
Pseudomonas strain BL072 produces an acylase enzyme active in hydrolyzing glutaryl-7-aminocephalosporanic acid to 7… Expand
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1993
1993
Enzymatic oxidation of cephalosporin C using whole cells of the yeast Triginopsis variabilis within a "cross-flow filter-reactor".
An economical process for the enzymatic oxidation of cephalosporin C to glutaryl-7-ACA was developed at a pilot plant scale. The… Expand
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1993
1993
Isolation and characterization of a pseudomonas strain producing glutaryl-7-aminocephalosporanic Acid acylase.
Several screening methods were developed for the selection of Pseudomonas strains capable of hydrolyzing glutaryl-7… Expand
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