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The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa
- P. Nadal Jimenez, G. Koch, Jessica A. Thompson, K. Xavier, R. Cool, W. Quax
- BiologyMicrobiology and Molecular Reviews
- 1 March 2012
This overview clearly illustrates that bacterial communication is far more complex than initially thought and delivers a clear distinction between signals that are quorum sensing dependent and those relying on alternative factors for their production.
Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome
- H. Tjalsma, H. Antelmann, J. V. van Dijl
- BiologyMicrobiology and Molecular Biology Reviews
- 1 June 2004
Proteomics has yielded a variety of novel leads for the analysis of protein traffic in B. subtilis and other gram-positive bacteria, which will serve to increase the understanding of virulence factor biogenesis in gram- positive pathogens, which is likely to be of high medical relevance.
Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1
The quorum-quenching AHL acylase may enable P. aeruginosa PAO1 to modulate its own quorum -sensing-dependent pathogenic potential and, moreover, offers possibilities for novel antipseudomonal therapies.
Bacillus subtilis as cell factory for pharmaceutical proteins: a biotechnological approach to optimize the host organism.
Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes.
The time course of the levels of artemisinin, its biosynthetic precursors and the biosynthetically related sesquiterpenes was monitored during a vegetation period of Artemisia annua plants of different geographical origin to suggest the presence of high levels of dihydroartemisinic acid may be an adaptation to stress conditions.
Seasonal variations of Artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the diploid wild-type.
Tetraploid A. annua can be a useful starting material for a breeding program in order to obtain larger and faster growing plants, which produce higher levels of artemisinin, and a reciprocal correlation between art Artemisinin (sesquiterpenes) and the essential oil content (monoterpenes).
Genome engineering reveals large dispensable regions in Bacillus subtilis.
It is shown that genome engineering is a feasible strategy for functional analysis of large gene clusters, and that removal of dispensable genomic regions may pave the way toward an optimized Bacillus cell factory.
Engineering Escherichia coli for methanol conversion.
Thiol-Disulfide Oxidoreductases Are Essential for the Production of the Lantibiotic Sublancin 168*
The present studies demonstrate that SunT and BdbB, but not BdbA, are required for the production of active sublancin 168, and show the unprecedented involvement of thiol-disulfide oxidoreductases in the synthesis of a peptide antibiotic.
Functional Analysis of Paralogous Thiol-disulfide Oxidoreductases in Bacillus subtilis *
- A. Bolhuis, G. Venemâ, W. Quax, S. Bron, J. V. van Dijl
- BiologyThe Journal of Biological Chemistry
- 27 August 1999
It is shown that the Gram-positive eubacteriumBacillus subtilis contains three genes, denotedbdbA, bdbB, and bdbC, for thiol-disulfide oxidoreductases, indicating that BdbB and BdbC have a general role in disulfide bond formation, whereas BdbA may be dedicated to a specific process.