W. Quax

Publications314
h-index54
Citations9,859
Highly Influential Citations391
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The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa
TLDR
This overview clearly illustrates that bacterial communication is far more complex than initially thought and delivers a clear distinction between signals that are quorum sensing dependent and those relying on alternative factors for their production.
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Proteomics of Protein Secretion by Bacillus subtilis: Separating the “Secrets” of the Secretome
TLDR
Proteomics has yielded a variety of novel leads for the analysis of protein traffic in B. subtilis and other gram-positive bacteria, which will serve to increase the understanding of virulence factor biogenesis in gram- positive pathogens, which is likely to be of high medical relevance.
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Quorum Quenching by an N-Acyl-Homoserine Lactone Acylase from Pseudomonas aeruginosa PAO1
TLDR
The quorum-quenching AHL acylase may enable P. aeruginosa PAO1 to modulate its own quorum -sensing-dependent pathogenic potential and, moreover, offers possibilities for novel antipseudomonal therapies.
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Bacillus subtilis as cell factory for pharmaceutical proteins: a biotechnological approach to optimize the host organism.
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Seasonal variation of artemisinin and its biosynthetic precursors in plants of Artemisia annua of different geographical origin: proof for the existence of chemotypes.
TLDR
The time course of the levels of artemisinin, its biosynthetic precursors and the biosynthetically related sesquiterpenes was monitored during a vegetation period of Artemisia annua plants of different geographical origin to suggest the presence of high levels of dihydroartemisinic acid may be an adaptation to stress conditions.
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Seasonal variations of Artemisinin and its biosynthetic precursors in tetraploid Artemisia annua plants compared with the diploid wild-type.
TLDR
Tetraploid A. annua can be a useful starting material for a breeding program in order to obtain larger and faster growing plants, which produce higher levels of artemisinin, and a reciprocal correlation between art Artemisinin (sesquiterpenes) and the essential oil content (monoterpenes).
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Genome engineering reveals large dispensable regions in Bacillus subtilis.
TLDR
It is shown that genome engineering is a feasible strategy for functional analysis of large gene clusters, and that removal of dispensable genomic regions may pave the way toward an optimized Bacillus cell factory.
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Engineering Escherichia coli for methanol conversion.
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Thiol-Disulfide Oxidoreductases Are Essential for the Production of the Lantibiotic Sublancin 168*
TLDR
The present studies demonstrate that SunT and BdbB, but not BdbA, are required for the production of active sublancin 168, and show the unprecedented involvement of thiol-disulfide oxidoreductases in the synthesis of a peptide antibiotic.
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Functional Analysis of Paralogous Thiol-disulfide Oxidoreductases in Bacillus subtilis *
TLDR
It is shown that the Gram-positive eubacteriumBacillus subtilis contains three genes, denotedbdbA, bdbB, and bdbC, for thiol-disulfide oxidoreductases, indicating that BdbB and BdbC have a general role in disulfide bond formation, whereas BdbA may be dedicated to a specific process.
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