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glutaminyl-peptide cyclotransferase activity

Known as: L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing), glutaminyl cyclase activity, glutaminyl-transfer ribonucleate cyclotransferase activity 
Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. [EC:2.3.2.5]
National Institutes of Health

Papers overview

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2018
2018
BackgroundPQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic… Expand
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2016
2016
Abstract Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This… Expand
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2011
2011
Acute and chronic inflammatory disorders are characterized by detrimental cytokine and chemokine expression. Frequently, the… Expand
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2005
2005
In stability studies during preclinical drug development, the human antimicrobial peptide hHEM-gamma 130-146 shows progressive N… Expand
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2004
2004
Summary1.Following the recent demonstration of a glutaminyl cyclase activity localized in adrenomedullary chromaffin vesicles, an… Expand
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2004
2004
A sensitive, rapid and reproducible assay for the determination of glutaminyl cyclase activity is reported. This method is based… Expand
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2002
2002
The enzymatic conversion of one chromogenic substrate, l-glutamine-p-nitroanilide, and two fluorogenic substrates, l-glutaminyl-2… Expand
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1998
1998
that achieved by TLC with numerous buffers (1,2,5) or by HV-TLE protocols (2) when multiple samples are analyzed. We have found… Expand
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1989
1989
Current assays for the glutaminyl-peptide cyclizing enzyme, glutaminyl cyclase, have several shortcomings. In this report a rapid… Expand
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1988
1988
A rapid, sensitive method for the quantification of glutaminyl cyclase activity has been developed. The assay involves enzymatic… Expand
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