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glutaminyl-peptide cyclotransferase activity

Known as: L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing), glutaminyl cyclase activity, glutaminyl-transfer ribonucleate cyclotransferase activity 
Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. [EC:2.3.2.5]
National Institutes of Health

Papers overview

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2016
2016
IsoQC (QPCTL) knock-out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes
Abstract Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This… 
2005
2005
In vitro degradation of the antimicrobial human peptide HEM-gamma 130-146 in plasma analyzed by a validated quantitative LC-MS/MS procedure.
2004
2004
Improved determination of bovine glutaminyl cyclase activity using precolumn derivatization and reversed-phase high-performance liquid chromatography with ultraviolet detection.
Highly Cited
2002
Highly Cited
2002
Continuous spectrometric assays for glutaminyl cyclase activity.
The enzymatic conversion of one chromogenic substrate, l-glutamine-p-nitroanilide, and two fluorogenic substrates, l-glutaminyl-2… 
1998
1998
In situ detection method for glutaminyl cyclase activity in polyacrylamide gels.
that achieved by TLC with numerous buffers (1,2,5) or by HV-TLE protocols (2) when multiple samples are analyzed. We have found… 
1990
1990
A novel 1745-dalton pyroglutamyl peptide derived from chromogranin B is in the bovine adrenomedullary chromaffin vesicle
Summary1.Following the recent demonstration of a glutaminyl cyclase activity localized in adrenomedullary chromaffin vesicles, an… 
1989
1989
A spectrophotometric assay for glutaminyl-peptide cyclizing enzymes
1988
1988
A rapid fluorometric assay for N-terminal glutaminyl cyclase activity using high-performance liquid chromatography.
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