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glutaminyl-peptide cyclotransferase activity

Known as: L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing), glutaminyl cyclase activity, glutaminyl-transfer ribonucleate cyclotransferase activity 
Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3. [EC:2.3.2.5]
National Institutes of Health

Papers overview

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2018
2018
BackgroundPQ912 is an inhibitor of the glutaminyl cyclase enzyme that plays a central role in the formation of synaptotoxic… Expand
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2016
2016
Abstract Secretory peptides and proteins are frequently modified by pyroglutamic acid (pE, pGlu) at their N-terminus. This… Expand
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Highly Cited
2011
Highly Cited
2011
Acute and chronic inflammatory disorders are characterized by detrimental cytokine and chemokine expression. Frequently, the… Expand
2005
2005
In stability studies during preclinical drug development, the human antimicrobial peptide hHEM-gamma 130-146 shows progressive N… Expand
2004
2004
Summary1.Following the recent demonstration of a glutaminyl cyclase activity localized in adrenomedullary chromaffin vesicles, an… Expand
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2004
2004
A sensitive, rapid and reproducible assay for the determination of glutaminyl cyclase activity is reported. This method is based… Expand
2002
2002
The enzymatic conversion of one chromogenic substrate, l-glutamine-p-nitroanilide, and two fluorogenic substrates, l-glutaminyl-2… Expand
1998
1998
that achieved by TLC with numerous buffers (1,2,5) or by HV-TLE protocols (2) when multiple samples are analyzed. We have found… Expand
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1989
1989
  • R. Bateman
  • Journal of Neuroscience Methods
  • 1989
  • Corpus ID: 42726863
Current assays for the glutaminyl-peptide cyclizing enzyme, glutaminyl cyclase, have several shortcomings. In this report a rapid… Expand
1988
1988
A rapid, sensitive method for the quantification of glutaminyl cyclase activity has been developed. The assay involves enzymatic… Expand