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Temporally resolved catecholamine spikes correspond to single vesicle release from individual chromaffin cells.
TLDR
These measurements represent time-resolved observation of quantal secretion of catecholamine and provide direct evidence for the exocytotic hypothesis. Expand
High-affinity neuropeptide Y receptor antagonists.
TLDR
The effects of three potent NPY receptor antagonists inhibiting specific radiolabeled NPY binding at Y1 and Y2 receptors and antagonizing the effects of NPY in human erythroleukemia cell intracellular calcium mobilization perfusion pressure in the isolated rat kidney, and mean arterial blood pressure in anesthetized rats are described. Expand
Opiate-like materials in the adrenal medulla: evidence for storage and secretion with catecholamines.
TLDR
Results indicate that enkephalins and other low molecular weight opiate-like materials are stored in and secreted from the chromaffin vesicles with catecholamines in the adrenal glands, and suggest that enkphalins may exert important neuroendocrine functions outside the central nervous system. Expand
Proportional secretion of opioid peptides and catecholamines from adrenal chromaffin cells in culture
TLDR
The results are consistent with the co-storage of opioid peptides and opiate receptor-inactive peptides containing enkephalin sequences in chromaffin vesicles and with the all- or-none exocytotic secretion of chromaff in vesicle content in response to stimulation of the adrenal medulla. Expand
Coordinate and differential regulation of phenylethanolamine N-methyltransferase, tyrosine hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary
TLDR
The results indicate that the level of TH, PNMT, and pEK mRNAs are regulated by direct neural and hormonal inputs to adrenal medullary cells and effects of acetylcholine could be mediated by cyclic AMP and alterations in catecholamine content. Expand
Regulation of tyrosine hydroxylase and phenylethanolamine N-methyltransferase mRNA levels in the sympathoadrenal system by the pituitary-adrenocortical axis.
TLDR
The findings suggest that the pituitary-adrenocortical axis is involved in the regulation of the steady-state levels of TH and PNMT mRNAs. Expand
The Crucial Role of Chromogranins in Storage and Exocytosis Revealed Using Chromaffin Cells from Chromogranin A Null Mouse
TLDR
It is concluded that intravesicular proteins are highly efficient systems directly implicated in transmitter accumulation and in the control of neurosecretion. Expand
Secretion of Catecholamines from Individual Adrenal Medullary Chromaffin Cells
TLDR
Catecholamine secretion has been measured with electrochemical techniques from isolated, single adrenal medullary chromaffin cells with carbon‐fiber microelectrodes and the actions of nicotine are found to continue for a longer period of time than those of the other secretagogues tested. Expand
Opioid peptides and noradrenaline co-exist in large dense-cored vesicles from sympathetic nerve
TLDR
It is concluded that opioid peptides are stored in the primary population of large dense-cord vesicles per se, rather than in a minor population of contaminating particles from cells other than sympathetic C-fibers, which has implications for exocytotic release and the physiological role of the opioid peptide intra- and extra-neuronally. Expand
Are opioid peptides co-transmitters in noradrenergic vesicles of sympathetic nerves?
TLDR
The results, reported here and based on direct biochemical analyses, indicate that OLPs, putative transmitters and noradrenaline probably coexist in sympathetic C-fibres, which constitute 98% of the bovine splenic nerve. Expand
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