glomerular visceral epithelial cell differentiation

Known as: podocyte differentiation 
The process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral… (More)
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Ectopic notch activation in developing podocytes causes glomerulosclerosis.
Genetic evidence supports an early role for Notch signaling in the fate of podocytes during glomerular development. Decreased… (More)
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2007
2007
Rapid screening of glomerular slit diaphragm integrity in larval zebrafish.
Gene array-type experiments have identified large numbers of genes thought to be important for the integrity of the glomerular… (More)
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Highly Cited
2006
Highly Cited
2006
Autocrine VEGF-A system in podocytes regulates podocin and its interaction with CD2AP.
Vascular endothelial growth factor (VEGF-A) signaling is required for endothelial cell differentiation, vasculogenesis… (More)
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Highly Cited
2005
Highly Cited
2005
TGF-beta concentration specifies differential signaling profiles of growth arrest/differentiation and apoptosis in podocytes.
Podocyte depletion occurs in most progressive glomerular diseases and is thought to result from podocyte loss while the remaining… (More)
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Highly Cited
2003
Highly Cited
2003
Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney.
Notch signaling is involved in pronephros development in Xenopus and in glomerulogenesis in mice. However, owing to early… (More)
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2002
2002
The mouse Kreisler (Krml1/MafB) segmentation gene is required for differentiation of glomerular visceral epithelial cells.
Molecular components of the glomerular filtration mechanism play critical roles in renal diseases. Many of these components are… (More)
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Highly Cited
2002
Highly Cited
2002
Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation.
LMX1B encodes a LIM-homeodomain transcription factor. Mutations in LMX1B cause nail-patella syndrome (NPS), an autosomal dominant… (More)
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Highly Cited
2002
Highly Cited
2002
HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes.
HIV-associated nephropathy (HIVAN) is now the third leading cause of end-stage renal disease in the African American population… (More)
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Highly Cited
2000
Highly Cited
2000
Podocyte cell cycle regulation and proliferation in collapsing glomerulopathies.
BACKGROUND Mature podocytes are growth-arrested because of the expression of cyclin-dependent kinase inhibitors. Under… (More)
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Highly Cited
1998
Highly Cited
1998
Pod-1, a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing kidney
Basic-helix-loop-helix (bHLH) proteins are transcriptional regulatory proteins that govern cell fate determination and… (More)
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