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Abnormal Extracellular Matrix Protein Transport Associated With Increased Apoptosis of Vascular Smooth Muscle Cells in Marfan Syndrome and Bicuspid Aortic Valve Thoracic Aortic Aneurysm
The findings suggest the presence of a fundamental cellular abnormality in BAV thoracic aorta, possibly of genetic origin, and alteration in both the amount and quality of secreted proteins and an increased degree of VSMC apoptosis in MS and BAV.
Rabbit models for the study of human atherosclerosis: from pathophysiological mechanisms to translational medicine.
Inflammatory reactions in the pathogenesis of atherosclerosis.
The mechanisms of atherogenic lipoproteins in terms of inflammatory reactions associated with hypercholesterolemia are addressed in order to develop novel therapeutic strategies to control, treat and prevent atherosclerosis in the future.
Podocyte Injury Promotes Progressive Nephropathy in Zucker Diabetic Fatty Rats
The zucker diabetic fatty (ZDF-fa/fa) rat is one of the attractive models for type II diabetes based on impaired glucose tolerance caused by the inherited insulin-resistance gene fa. Characterization…
Macrophage Metalloelastase Accelerates the Progression of Atherosclerosis in Transgenic Rabbits
The results suggest that macrophage-derived MMP-12 participates in the progression of atherosclerosis, and may play a pivotal role in the cascade activation of other MMPs, thereby exacerbating extracellular matrix degradation during the progress of Atherosclerosis.
Overexpression of peroxiredoxin 4 protects against high-dose streptozotocin-induced diabetes by suppressing oxidative stress and cytokines in transgenic mice.
Data indicate that PRDX4 can protect pancreatic islet β-cells against injury caused by SHDS-induced insulitis, which strongly suggests that oxidative stress plays an essential role in SH DS-induced diabetes.
Transgenic rabbits as therapeutic protein bioreactors and human disease models.
Overexpression of human matrix metalloproteinase-12 enhances the development of inflammatory arthritis in transgenic rabbits.
Increased expression of vascular endothelial growth factor in kidney leads to progressive impairment of glomerular functions.
- Enqi Liu, M. Morimoto, Jianglin Fan
- Medicine, BiologyJournal of the American Society of Nephrology…
- 1 July 2007
This study provides the first evidence that increased expression of V EGF in glomeruli directly causes the glomerular hypertrophy that is associated with proteinuria, suggesting that VEGF exerts multiple effects on the glomersular pathophysiologic processes.
Human C-Reactive Protein Does Not Promote Atherosclerosis in Transgenic Rabbits
HCRP was indeed present in the lesions but did not affect macrophage accumulation and smooth muscle cell proliferation of the lesions, and neither high nor low plasma concentrations of hCRP affected aortic or coronary atherosclerosis lesion formation in h CRP-Tg rabbits.