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glaziovianin A

 
National Institutes of Health

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Isoflavones

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2019
2019
Synthesis of Isoflavones by Tandem Demethylation and Ring-Opening/Cyclization of Methoxybenzoylbenzofurans.
The unexpected conversion of benzoylbenzofurans into isoflavones through an intramolecular cascade that involves deprotection and… Expand
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2016
2016
Efficient Synthesis of Glaziovianin A Isoflavone Series from Dill and Parsley Extracts and Their in Vitro/in Vivo Antimitotic Activity.
A concise six-step protocol for the synthesis of isoflavone glaziovianin A (GVA) and its alkoxyphenyl derivatives 9 starting with… Expand
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2016
2016
Discovery of O6-benzyl glaziovianin A, a potent cytotoxic substance and a potent inhibitor of α,β-tubulin polymerization.
We have discovered O6-benzyl glaziovianin A, which showed stronger inhibition of microtubule polymerization (IC50=2.1μM) than… Expand
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2015
2015
The γ-tubulin-specific inhibitor gatastatin reveals temporal requirements of microtubule nucleation during the cell cycle
Inhibitors of microtubule (MT) assembly or dynamics that target α/β-tubulin are widely exploited in cancer therapy and biological… Expand
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Review
2015
Review
2015
[Discovery of Novel Biologically Active Compounds of Natural Origin, with a Focus on Anti-tumor Activity].
  • Akihito Yokosuka
  • Yakugaku zasshi : Journal of the Pharmaceutical…
  • 2015
    • Corpus ID: 36333661
Numerous clinically valuable medicines, including anticancer drugs, have been developed from biologically active natural… Expand
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2014
2014
Analysis of the Effect of Glaziovianin A and the Derivatives on Microtubule Dynamics
 
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2013
2013
Glaziovianin A prevents endosome maturation via inhibiting microtubule dynamics.
Glaziovianin A, an isoflavone isolated from the leaves of Ateleia glazioviana, inhibits the cell cycle progression in M-phase… Expand
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2012
2012
Design, synthesis, and biological evaluation of the analogues of glaziovianin A, a potent antitumor isoflavone.
Various analogues of glaziovianin A, an antitumor isoflavone, were synthesized, and their biological activities were evaluated. O… Expand
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2010
2010
Structure-activity relationship study of glaziovianin A against cell cycle progression and spindle formation of HeLa S3 cells.
Various derivatives of glaziovianin A, an antitumor isoflavone, were synthesized, and the cytotoxicity of each against HeLa S3… Expand
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2007
2007
Glaziovianin A, a new isoflavone, from the leaves of Ateleia glazioviana and its cytotoxic activity against human cancer cells.
A new isoflavone, named glaziovianin A (1), was isolated from the leaves of Ateleia glazioviana (Legminosae) by means of a… Expand
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