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gephyrin

Known as: MPT Adenylyltransferase, Domain E, Molybdopterin Adenylyltransferase 
Gephyrin (736 aa, ~80 kDa) is encoded by the human GPHN gene. This protein is involved in biosynthesis of the molybdenum cofactor.
National Institutes of Health

Related topics

Related topics

7 relations
AnabolismCytoplasmEnzyme GeneGPHN gene

Broader (2)

Carrier ProteinsMembrane Proteins

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Palmitoylation of Gephyrin Controls Receptor Clustering and Plasticity of GABAergic Synapses
Gephyrin, the principal scaffolding protein at inhibitory synapses, needs to be palmitoylated in order to cluster and to assemble… 
Highly Cited
2011
Highly Cited
2011
Molecular Basis of the γ-Aminobutyric Acid A Receptor α3 Subunit Interaction with the Clustering Protein Gephyrin*
Background: The molecular basis of GABAA receptor α3 subtype-specific synaptic localization is unknown. Results: GABAAR α3… 
Highly Cited
2008
Highly Cited
2008
Homeostatic Regulation of Synaptic GlyR Numbers Driven by Lateral Diffusion
Highly Cited
2006
Highly Cited
2006
Neuronal cotransport of glycine receptor and the scaffold protein gephyrin
The dynamics of postsynaptic receptor scaffold formation and remodeling at inhibitory synapses remain largely unknown. Gephyrin… 
Highly Cited
2004
Highly Cited
2004
The GDP-GTP Exchange Factor Collybistin: An Essential Determinant of Neuronal Gephyrin Clustering
Glycine receptors (GlyRs) and specific subtypes of GABAA receptors are clustered at synapses by the multidomain protein gephyrin… 
Highly Cited
2001
Highly Cited
2001
Fast and reversible trapping of surface glycine receptors by gephyrin
Variations in receptor number at a given synapse are known to contribute to synaptic plasticity, but methods used to establish… 
Highly Cited
1996
Highly Cited
1996
Colocalization of GABA, glycine, and their receptors at synapses in the rat spinal cord
To determine whether GABA and glycine can act as cotransmitters at synapses in the rat spinal cord, we have compared the… 
Highly Cited
1995
Highly Cited
1995
The postsynaptic localization of the glycine receptor-associated protein gephyrin is regulated by the cytoskeleton
The mechanisms underlying the postsynaptic localization of neurotransmitter receptors are poorly understood. Recently, the… 
Highly Cited
1995
Highly Cited
1995
Colocalization of gephyrin and GABAA‐receptor subunits in the rat retina
Gephyrin is a protein that copurifies with the glycine receptor (GlyR) and is required for the clustering of GlyRs at… 
Highly Cited
1993
Highly Cited
1993
Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons
EACH neuron in the mammalian brain carries many postsynaptic membrane specializations containing high densities of receptors that… 
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