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geneseroline

National Institutes of Health

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Alkaloids

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2006
2006
Structural determinants of Torpedo californica acetylcholinesterase inhibition by the novel and orally active carbamate based anti-alzheimer drug ganstigmine (CHF-2819).
Ganstigmine is an orally active, geneserine derived, carbamate-based acetylcholinesterase inhibitor developed for the treatment… 
2001
2001
Phase I metabolism of ganstigmine. Rat, dog, monkey and human liver microsomal extracts investigated by liquid chromatography electrospray tandem mass spectrometry.
Ganstigmine, a new acetylcholinesterase inhibitor, was incubated with rat liver microsomes and the resulting metabolites were… 
1995
1995
Solution- and solid-state structures of the (-)-n-heptylcarbamate of geneseroline and its hydrochloride salt.
The solid state structures of the (-)-n-heptylcarbamate of geneseroline and its hydrochloride salt were determined by single… 
1989
1989
Geneserine and geneseroline revisited: acid-base catalyzed equilibria of hexahydropyrrolo-[2,3-b]-indole N-oxides with hexahydro-1,2-oxazino-[5,6-b]-indoles.
It is shown that geneserine [2] and geneseroline [4] convert with acid into salts of physostigmine N-oxide [3] and geneseroline N… 
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