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gamma-Globins

Known as: gamma-Globin, gamma globin, globin gamma 
Members of the beta-globin family. In humans, two non-allelic types of gamma-globin - A gamma and G gamma are encoded in the beta-globin gene cluster… 
National Institutes of Health

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Globin
Process of secretionagonistsantagonists & inhibitorsaspects of radiation effects

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Role of the GATA-1/FOG-1/NuRD Pathway in the Expression of Human β-Like Globin Genes
ABSTRACT The human β-globin genes are expressed in a developmentally controlled fashion. Studies on the molecular mechanisms… 
Highly Cited
2006
Highly Cited
2006
Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves gamma-globin activation by CREB1 and ATF-2.
The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate gamma-globin expression via a p38 mitogen… 
Highly Cited
2004
Highly Cited
2004
Increased soluble guanylate cyclase activity in the red blood cells of sickle cell patients
Activation of soluble guanylate cyclase (sGC) has been reported to up‐regulate γ‐globin gene transcription in erythroid cell… 
Highly Cited
1999
Highly Cited
1999
The DNA‐binding drugs mithramycin and chromomycin are powerful inducers of erythroid differentiation of human K562 cells
The human leukaemic K562 cell line can be induced in vitro to undergo erythroid differentiation by a variety of chemical… 
Highly Cited
1997
Highly Cited
1997
Induction of gamma-globin by histone deacetylase inhibitors.
The short-chain fatty acid butyrate has been shown to elevate fetal hemoglobin (HbF) by inducing expression of the gamma-globin… 
Highly Cited
1992
Highly Cited
1992
4-Hydroxynonenal, a product of cellular lipid peroxidation, which modulates c-myc and globin gene expression in K562 erythroleukemic cells.
Several studies point to the existence of an inverse correlation between cellular lipid peroxidation and both cell proliferation… 
Highly Cited
1990
Highly Cited
1990
Function of normal and mutated gamma-globin gene promoters in electroporated K562 erythroleukemia cells.
We examined the importance of cis-acting regulatory elements of the human gamma-globin gene promoter in a cell line (K562) where… 
Highly Cited
1989
Highly Cited
1989
The human beta-globin locus activation region alters the developmental fate of a human fetal globin gene in transgenic mice.
We linked a 3.3-kilobase fragment containing the entire A gamma-globin gene together with 1.3 kilobases of 5' flanking and 0.37… 
Highly Cited
1988
Highly Cited
1988
The −117 mutation in Greek HPFH affects the binding of three nuclear factors to the CCAAT region of the gamma‐globin gene.
The Greek form of hereditary persistence of fetal hemoglobin (HPFH) is associated with a point mutation immediately upstream of… 
Highly Cited
1985
Highly Cited
1985
Developmental regulation of human globin genes in transgenic mice.
gamma-globin genes in transgenic mice. 
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