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furazlocillin

Known as: (2S-(2 alpha,5 alpha,6 beta(S*)))-6-(((((3-((2-furanylmethylene)amino)-2-oxo-1-imidazolidinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(D-2-(3-furfurylidenamino-2-oxoimidazolidine-1-carboxamido)-2-(4-hydroxyphenyl)acetamido)penicillanic acid, Fuzlocillin 
A semisynthetic acylureidopenicillin with antibacterial activity. Fuzlocillin binds to and inactivates penicillin-binding proteins (PBPs) located on… Expand
National Institutes of Health

Papers overview

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Highly Cited
1998
Highly Cited
1998
The localization of FtsI (PBP3), a penicillin-binding protein specifically required for cell division in Escherichia coli, was… Expand
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Highly Cited
1992
Highly Cited
1992
A deletion in the structural gene for the soluble lytic transglycosylase, the predominant murein hydrolase in the soluble… Expand
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1991
1991
Blocking of penicillin-binding proteins (PBP) 2 or 3 of Escherichia coli by specific antibiotics led to inhibition of… Expand
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Highly Cited
1989
Highly Cited
1989
The rate at which the peptidoglycan of Escherichia coli is synthesized during the division cycle was studied with two methods… Expand
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1988
1988
The pbpB gene product penicillin-binding protein 3 (PBP3) of Escherichia coli is one of the major targets of beta-lactam… Expand
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1986
1986
Mutations in the ftsA gene of Escherichia coli conferred a higher resistance to lysis induced by penicillin or by a combination… Expand
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1982
1982
Cells of Escherichia coli PA3092 were synchronized by centrifugal elutriation. The synchronously growing cells were double… Expand
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Highly Cited
1981
Highly Cited
1981
Furazlocillin (1 microgram/ml) and piperacillin (5 microgram/ml) bound specifically to penicillin-binding protein 3 (PBP-3) and… Expand
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1981
1981
Furazlocillin binds selectively to penicillin-binding protein 3 (PBP-3), prevents septation of Escherichia coli, and allows the… Expand
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1979
1979
The activity of furazlocillin (Bay k 4999) was compared with those of mezlocillin, piperacillin, and standard beta-lactam… Expand
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