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Multilocus sequence typing: a portable approach to the identification of clones within populations of pathogenic microorganisms.
TLDR
Multilocus sequence typing (MLST), which exploits the unambiguous nature and electronic portability of nucleotide sequence data for the characterization of microorganisms, can be applied to almost all bacterial species and other haploid organisms, including those that are difficult to cultivate. Expand
Multilocus sequence typing for characterization of methicillin-resistant and methicillin-susceptible clones of Staphylococcus aureus.
TLDR
The most prevalent MRSA clone was very closely related to EMRSA-16, and the success of the latter clone at causing disease in hospitals may be due to its emergence from a virulent MSSA clone that was already a major cause of invasive disease in both the community and hospital settings. Expand
How clonal are bacteria?
TLDR
Data from multilocus enzyme electrophoresis of bacterial populations were analyzed using a statistical test designed to detect associations between genes at different loci, and found panmictic, epidemic, and clonal population structures. Expand
The evolutionary history of methicillin-resistant Staphylococcus aureus (MRSA)
TLDR
This work analyzes an international collection of 912 MRSA and methicillin-susceptible S. aureus isolates to establish the likely evolutionary origins of each major MRSA clone, the genotype of the original MRSAclone and its MSSA progenitor, and the extent of acquisition and horizontal movement of the methiillin resistance genes. Expand
eBURST: inferring patterns of evolutionary descent among clusters of related bacterial genotypes from multilocus sequence typing data.
TLDR
A new implementation of eBURST is presented, which divides an MLST data set of any size into groups of related isolates and clonal complexes, predicts the founding (ancestral) genotype of each clonal complex, and computes the bootstrap support for the assignment. Expand
A multilocus sequence typing scheme for Streptococcus pneumoniae: identification of clones associated with serious invasive disease.
TLDR
A pneumococcal multilocus sequence typing scheme and database is developed by sequencing approximately 450 bp fragments of seven housekeeping loci from 295 isolates to provide an allelic profile, or sequence type (ST), and the relatedness between isolates was obtained by constructing a dendrogram from the matrix of pairwise differences between STs. Expand
Complete DNA sequence of a serogroup A strain of Neisseria meningitidis Z2491
TLDR
The complete genome sequence of a serogroup A strain of Neisseria meningitidis, Z2491, is determined and the most notable feature of the genome is the presence of many hundreds of repetitive elements, ranging from short repeats, positioned either singly or in large multiple arrays, to insertion sequences and gene duplications of one kilobase or more. Expand
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
TLDR
The crucial role that accessory elements play in the rapid evolution of S. aureus is clearly illustrated by comparing the MSSA476 genome with that of an extremely closely related MRSA community-acquired strain; the differential distribution of large mobile elements carrying virulence and drug-resistance determinants may be responsible for the clinically important phenotypic differences in these strains. Expand
Multilocus Sequence Typing System for Group B Streptococcus
TLDR
The GBS MLST system offers investigators a valuable typing tool that will promote further investigation of the population biology of this organism and suggests that recombination occurs at the capsular locus. Expand
How clonal is Staphylococcus aureus?
TLDR
Examination of the sequence changes at MLST loci during clonal diversification shows that point mutations give rise to new alleles at least 15-fold more frequently than does recombination, which suggests that homologous recombination does contribute toward the evolution of this species over the long term. Expand
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