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fms-Like Tyrosine Kinase 3

Known as: CD135 Antigen, Fetal Liver Kinase-2, Fetal Liver Kinase-3 
A receptor tyrosine kinase that is involved in HEMATOPOIESIS. It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute… 
National Institutes of Health

Related topics

Related topics

11 relations
FLT3 geneImmunoglobulin DomainsIn BloodProcess of secretion

Narrower (1)

FLT3 protein, human

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2017
Review
2017
Arylurea Derivatives: A Class of Potential Cancer Targeting Agents.
Arylurea derivatives, an important class of small molecules, have received considerable attention in recent years due to their… 
2017
2017
Design and synthesis of a fluorinated quinazoline-based type-II Trk inhibitor as a scaffold for PET radiotracer development.
2015
2015
Synergistic effect of all‑trans retinoic acid in combination with protein kinase C 412 in FMS-like tyrosine kinase 3-mutated acute myeloid leukemia cells.
Acute myeloid leukemia (AML) is a heterogeneous disease. Numerous molecular abnormalities have been identified in AML and… 
Review
2012
Review
2012
Molecular targeted therapy in acute myeloid leukemia
The treatment of acute myeloid leukemia has not changed significantly over the last 40 years. Recent progress in understanding… 
Highly Cited
2011
Highly Cited
2011
Protein-tyrosine Phosphatase DEP-1 Controls Receptor Tyrosine Kinase FLT3 Signaling*
Fms-like tyrosine kinase 3 (FLT3) plays an important role in hematopoietic differentiation, and constitutively active FLT3 mutant… 
2009
2009
Bis(1H‐indol‐2‐yl)methanones are effective inhibitors of FLT3‐ITD tyrosine kinase and partially overcome resistance to PKC412A in vitro
Inhibition of the mutated fms‐like tyrosine kinase 3 (FLT3) receptor tyrosine kinase is a promising therapeutic strategy in acute… 
2009
2009
A substrate peptide for the FLT3 receptor tyrosine kinase
FLT3 (fms‐like tyrosine kinase 3) is frequently activated by mutation in acute myeloid leukemia, and is therefore under study as… 
Review
2008
Review
2008
Recent advances in management of acute myeloid leukemia (AML)
Acute myeloid leukemia (AML) is the most common childhood malignancy. AML has therapentically been difficult to treat. In 2001… 
2002
2002
SU 5416 and SU 5614 inhibit kinase activity of wild-type and mutant FLT 3 receptor tyrosine kinase
Internal tandem duplication (ITD) in the juxtamembrane portion of Fms-like tyrosine kinase 3 (FLT3), a type III receptor tyrosine… 
1994
1994
Fms-like tyrosine kinase 3 catalytic domain can transduce a proliferative signal in FDC-P1 cells that is qualitatively similar to the signal delivered by c-Fms.
A full length clone of murine fms-like tyrosine kinase 3 [flt3, also known as fetal liver kinase 2 (flk2)] was constructed from… 
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