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fluorosalinosporamide

 
National Institutes of Health

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2 relations

Broader (2)

Hydrocarbons, FluorinatedLactones

Papers overview

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2011
2011
The discovery of salinosporamide K from the marine bacterium "Salinispora pacifica" by genome mining gives insight into pathway evolution.
The γ-lactam-β-lactone natural product salinosporamide A (1) is a potent proteasome inhibitor produced by the marine bacterium… Expand
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2010
2010
Engineering fluorometabolite production: fluorinase expression in Salinispora tropica Yields Fluorosalinosporamide.
Organofluorine compounds play an important role in medicinal chemistry, where they are responsible for up to 15% of the… Expand
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2009
2009
Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition.
Many marketed drugs contain fluorine, reflecting its ability to modulate a variety of biological responses. The unique 20S… Expand
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2008
2008
Leaving groups prolong the duration of 20S proteasome inhibition and enhance the potency of salinosporamides.
Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome inhibitor in clinical trials for the treatment of… Expand
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2008
2008
Mutasynthesis of fluorosalinosporamide, a potent and reversible inhibitor of the proteasome.
 
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