fluorosalinosporamide
National Institutes of Health
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The γ-lactam-β-lactone natural product salinosporamide A (1) is a potent proteasome inhibitor produced by the marine bacterium…
Organofluorine compounds play an important role in medicinal chemistry, where they are responsible for up to 15% of the…
Many marketed drugs contain fluorine, reflecting its ability to modulate a variety of biological responses. The unique 20S…
Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome inhibitor in clinical trials for the treatment of…