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Metabotropic glutamate receptor 5 (mGluR5) represents a potential therapeutic target for Huntington disease. Using 11C-ABP688 (3… Expand Introduction: A 37-year-old man was referred for PET/CT with the following diagnostic challenge: a longstanding smoking history… Expand How to Cite Evdokimov, N. M.; Flores, G.; Clark, P. M.; Phelps, M. E.; Witte, O. N.; Jung, M. E. Chem. Heterocycl. Compd. 2014… Expand BACKGROUND
Sleep deprivation (wake therapy) provides rapid clinical relief in many patients with major depressive disorder (MDD… Expand Abnormal glutamate transmission is involved in various neurologic disorders, such as epilepsy, schizophrenia, and Parkinson… Expand BACKGROUND
An imaging method to probe glutamate levels in vivo would allow the study of glutamate transmission in disease states… Expand Activation of astrocytic metabotropic glutamate receptor 5 (mGluR5) is postulated to elicit calcium transients, triggering a… Expand (E)-3-(pyridin-2-ylethynyl)cyclohex-2-enone O-2-(2-(18)F-fluoroethoxy)ethyl oxime, ([(18)F]-FDEGPECO), a novel high affinity… Expand UNLABELLED
(11)C-ABP-688 is a selective tracer for the mGluR5 receptor. Its kinetics is fast and thus favourable for an… Expand INTRODUCTION
Fluoroethyl-desmethyl-ABP688 (FE-DABP688) is a novel derivative of the previously described positron emission… Expand