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finafloxacin

Known as: gastroquinolone, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
 
National Institutes of Health

Related topics

Related topics

3 relations
Finafloxacin:Susc:Pt:Isolate:OrdQnFinafloxacin:Susc:Pt:Isolate:OrdQn:Agar diffusion

Broader (1)

Fluoroquinolones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Chemical structure and pharmacokinetics of novel quinolone agents represented by avarofloxacin, delafloxacin, finafloxacin, zabofloxacin and nemonoxacin
Quinolones are potent antimicrobial agents with a basic chemical structure of bicyclic ring. Fluorine atom at position C-6 and… Expand
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Review
2015
Review
2015
Finafloxacin: First Global Approval
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. It is being… Expand
Highly Cited
2011
Highly Cited
2011
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
ABSTRACT Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim… Expand
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2011
2011
Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.
Finafloxacin, an 8-cyano-substituted fluoroquinolone, expresses enhanced activity at acidic pH and is less susceptible to several… Expand
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2011
2011
Comparative In Vitro Activities of the Novel Antibacterial Finafloxacin against Selected Gram-Positive and Gram-Negative Bacteria Tested in Mueller-Hinton Broth and Synthetic Urine
ABSTRACT Kill kinetics and MICs of finafloxacin and ciprofloxacin against 34 strains with defined resistance mechanisms grown in… Expand
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2011
2011
Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose
Background: Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. Methods… Expand
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2011
2011
Comparative in vitro activity of finafloxacin against staphylococci displaying normal and small colony variant phenotypes.
OBJECTIVES Staphylococcal small colony variants (SCVs) are associated with chronic and relapsing infections and their… Expand
2011
2011
Human Pharmacokinetics and Safety Profile of Finafloxacin, a New Fluoroquinolone Antibiotic, in Healthy Volunteers †
ABSTRACT Finafloxacin is a new fluoroquinolone antibiotic with the unique property of increasing antibacterial activity at pH… Expand
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Highly Cited
2010
Highly Cited
2010
Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
ABSTRACT This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH… Expand
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2010
2010
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.
OBJECTIVES Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly… Expand
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