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finafloxacin

Known as: gastroquinolone, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
National Institutes of Health

Related topics

Related topics

3 relations
Finafloxacin:Susc:Pt:Isolate:OrdQnFinafloxacin:Susc:Pt:Isolate:OrdQn:Agar diffusion

Broader (1)

Fluoroquinolones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Demonstration of the Broad-Spectrum In Vitro Activity of Finafloxacin against Pathogens of Biodefense Interest
This study investigated the in vitro activity of finafloxacin against bacterial strain panels of the biodefense pathogens. Broth… 
2018
2018
Explorative Randomized Phase II Clinical Study of the Efficacy and Safety of Finafloxacin versus Ciprofloxacin for Treatment of Complicated Urinary Tract Infections
ABSTRACT The broad-spectrum C-8-cyano-fluoroquinolone finafloxacin displays enhanced activity under acidic conditions. This phase… 
2018
2018
Early Clinical Assessment of the Antimicrobial Activity of Finafloxacin Compared to Ciprofloxacin in Subsets of Microbiologically Characterized Isolates
ABSTRACT Two phase II studies were performed with patients with uncomplicated urinary tract infections (uUTIs) and complicated… 
2017
2017
Demonstrating the Protective Efficacy of the Novel Fluoroquinolone Finafloxacin against an Inhalational Exposure to Burkholderia pseudomallei
ABSTRACT Burkholderia pseudomallei is the causative agent of melioidosis, a serious disease endemic in Southeast Asia and… 
2017
2017
Pharmacodynamics of Finafloxacin, Ciprofloxacin, and Levofloxacin in Serum and Urine against TEM- and SHV-Type Extended-Spectrum-β-Lactamase-Producing Enterobacteriaceae Isolates from Patients with…
ABSTRACT The pharmacodynamics of finafloxacin, ciprofloxacin, and levofloxacin against extended-spectrum-β-lactamase (ESBL… 
2017
2017
Pharmacokinetics of Intravenous Finafloxacin in Healthy Volunteers
ABSTRACT Finafloxacin is a novel fluoroquinolone exhibiting enhanced activity under acidic conditions and a broad-spectrum… 
2015
2015
High Efficacy of Finafloxacin on Helicobacter pylori Isolates at pH 5.0 Compared with That of Other Fluoroquinolones
ABSTRACT Finafloxacin is a novel fluoroquinolone with improved antimicrobial efficacy, especially in an acidic environment. The… 
Highly Cited
2011
Highly Cited
2011
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
ABSTRACT Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim… 
2008
2008
Comparative Activity Between Finafloxacin (FIN) and Other Fluoroquinolones Against Bacterial and Eukaryotic Type II Topoisomerases
tr t Introduction I tr ti Conclusions l i Methods t Literature it r t r [1] Wohlert et al., 48th ICAAC, Washington DC 2008… 
2008
2008
Antimicrobial Activity of Finafloxacin (FIN) against Helicobacter pylori In Vitro and In Vivo
FIN exhibits improved antibacterial activity, under conditions of acidic pH, against a wide range of species [1,2]. Under the… 
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