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finafloxacin

Known as: gastroquinolone, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid 
National Institutes of Health

Related topics

Related topics

3 relations
Finafloxacin:Susc:Pt:Isolate:OrdQnFinafloxacin:Susc:Pt:Isolate:OrdQn:Agar diffusion

Broader (1)

Fluoroquinolones

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Fluoroquinolones structural and medicinal developments (2013-2018): Where are we now?
Review
2016
Review
2016
The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?
ABSTRACT Introduction: A real concern in the medical community is the increasing resistance of bacteria, especially that of Gram… 
Review
2015
Review
2015
Finafloxacin: First Global Approval
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. It is being… 
Review
2015
Review
2015
Finafloxacin for the treatment of urinary tract infections
Introduction: In the past decade, the indiscriminate use of fluoroquinolones in the prophylaxis and treatment of urinary tract… 
Highly Cited
2011
Highly Cited
2011
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
ABSTRACT Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim… 
Highly Cited
2011
Highly Cited
2011
Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.
2011
2011
Human Pharmacokinetics and Safety Profile of Finafloxacin, a New Fluoroquinolone Antibiotic, in Healthy Volunteers
ABSTRACT Finafloxacin is a new fluoroquinolone antibiotic with the unique property of increasing antibacterial activity at pH… 
Highly Cited
2010
Highly Cited
2010
Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
ABSTRACT This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH… 
2010
2010
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.
OBJECTIVES Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly… 
2008
2008
Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose
Background: Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. Methods… 
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