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finafloxacin
Known as:
gastroquinolone
, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b][1,4]oxazin-6(2H)-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid
, 8-Cyano-1-cyclopropyl-6-fluoro-7-[(4aS,7aS)-hexahydropyrrolo[3,4-b]-1,4-oxazin-6(2H)-yl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
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National Institutes of Health
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Related topics
Related topics
3 relations
Finafloxacin:Susc:Pt:Isolate:OrdQn
Finafloxacin:Susc:Pt:Isolate:OrdQn:Agar diffusion
Broader (1)
Fluoroquinolones
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
Fluoroquinolones structural and medicinal developments (2013-2018): Where are we now?
G. Suaifan
,
Aya A. M. Mohammed
Bioorganic & Medicinal Chemistry
2019
Corpus ID: 184486231
Review
2016
Review
2016
The antibiotic pipeline for multi-drug resistant gram negative bacteria: what can we expect?
M. Falagas
,
A. Mavroudis
,
K. Vardakas
Expert Review of Anti-Infective Therapy
2016
Corpus ID: 205850100
ABSTRACT Introduction: A real concern in the medical community is the increasing resistance of bacteria, especially that of Gram…
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Review
2015
Review
2015
Finafloxacin: First Global Approval
K. McKeage
Drugs
2015
Corpus ID: 207488603
Finafloxacin is a fluoroquinolone antimicrobial agent that exhibits optimum efficacy in slightly acidic environments. It is being…
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Review
2015
Review
2015
Finafloxacin for the treatment of urinary tract infections
R. Bartoletti
,
T. Cai
,
G. Perletti
,
Florian ME Wagenlehner
,
T. B. Bjerklund Johansen
Expert Opinion on Investigational Drugs
2015
Corpus ID: 27148906
Introduction: In the past decade, the indiscriminate use of fluoroquinolones in the prophylaxis and treatment of urinary tract…
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Highly Cited
2011
Highly Cited
2011
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
W. Stubbings
,
Pamela Leow
,
+5 authors
H. Labischinski
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 26387313
ABSTRACT Finafloxacin is a novel fluoroquinolone that exhibits enhanced antibacterial activity under acidic conditions. The aim…
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Highly Cited
2011
Highly Cited
2011
Activity of finafloxacin, a novel fluoroquinolone with increased activity at acid pH, towards extracellular and intracellular Staphylococcus aureus, Listeria monocytogenes and Legionella pneumophila.
S. Lemaire
,
F. Van Bambeke
,
P. Tulkens
International Journal of Antimicrobial Agents
2011
Corpus ID: 5545841
2011
2011
Human Pharmacokinetics and Safety Profile of Finafloxacin, a New Fluoroquinolone Antibiotic, in Healthy Volunteers
H. Patel
,
A. Andresen
,
+6 authors
H. Labischinski
Antimicrobial Agents and Chemotherapy
2011
Corpus ID: 2117813
ABSTRACT Finafloxacin is a new fluoroquinolone antibiotic with the unique property of increasing antibacterial activity at pH…
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Highly Cited
2010
Highly Cited
2010
Activity of the Investigational Fluoroquinolone Finafloxacin against Ciprofloxacin-Sensitive and -Resistant Acinetobacter baumannii Isolates
P. Higgins
,
W. Stubbings
,
H. Wisplinghoff
,
H. Seifert
Antimicrobial Agents and Chemotherapy
2010
Corpus ID: 43522471
ABSTRACT This study compared the activity of finafloxacin, a novel fluoroquinolone which shows enhanced activity under acidic pH…
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2010
2010
Antibacterial activity of finafloxacin under different pH conditions against isogenic strains of Escherichia coli expressing combinations of defined mechanisms of fluoroquinolone resistance.
Nadine-C Emrich
,
A. Heisig
,
W. Stubbings
,
H. Labischinski
,
P. Heisig
Journal of Antimicrobial Chemotherapy
2010
Corpus ID: 2281219
OBJECTIVES Finafloxacin is an investigational fluoroquinolone exhibiting broad-spectrum activity that is enhanced under slightly…
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2008
2008
Urinary Pharmacokinetics and Bactericidal Activity of Finafloxacin (200 and 800 mg) in Healthy Volunteers Receiving a Single Oral Dose
F. Wagenlehner
,
C. Wagenlehner
,
+4 authors
K. Naber
Chemotherapy
2008
Corpus ID: 6555321
Background: Finafloxacin is a novel 8-cyano-fluoroquinolone under investigation for treatment of urinary tract infection. Methods…
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