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filibuvir

Known as: (6R)-6-Cyclopentyl-6-(2-(2,6-Diethylpyridin-4-yl)Ethyl)-3-((5,7-Dimethyl(1,2,4)Triazolo(1,5- A)Pyrimidin-2-yl)Methyl)-4-Hydroxy-5,6-Dihydro-2H-Pyran-2-One, 2H-Pyran-2-One, 6-Cyclopentyl-6-(2-(2,6-Diethyl-4-Pyridinyl)Ethyl)-3-((5,7-Dimethyl(1,2,4)Triazolo(1,5-A)Pyrimidin-2-yl)Methyl)-5,6-Dihydro-4-Hydroxy-, (6R)- 
A non-nucleoside polymerase inhibitor of the hepatitis C virus NS5B RNA-dependent RNA polymerase. Filibuvir binds to the non-catalytic Thumb 2 site… 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

PF 00868554

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2017
2017
NMR reveals the intrinsically disordered domain 2 of NS5A protein as an allosteric regulator of the hepatitis C virus RNA polymerase NS5B
Non-structural protein 5B (NS5B) is the RNA-dependent RNA polymerase that catalyzes replication of the hepatitis C virus (HCV… 
2015
2015
Computational study on the drug resistance mechanism of HCV NS5B RNA-dependent RNA polymerase mutants V494I, V494A, M426A, and M423T to Filibuvir.
2013
2013
Resolution of the interaction mechanisms and characteristics of non-nucleoside inhibitors of hepatitis C virus polymerase.
2012
2012
Determination and control of TEMPO, a potentially genotoxic free radical reagent used in the synthesis of filibuvir.
2012
2012
Pharmacokinetic / Pharmacodynamic Predictors of Clinical Potency for 1 Hepatitis C Non-Nucleoside Polymerase and Protease Inhibitors 2 3
1 Hepatitis C Non-Nucleoside Polymerase and Protease Inhibitors 2 3 Authors: Micaela B. Reddy, Peter N. Morcos, Sophie Le Pogam… 
2011
2011
Antiviral activity of the hepatitis C virus polymerase inhibitor filibuvir in genotype 1–infected patients
More effective and better‐tolerated therapies are needed for chronic hepatitis C virus (HCV) infection. Among the direct‐acting… 
2011
2011
Characterization of Resistance to the Nonnucleoside NS5B Inhibitor Filibuvir in Hepatitis C Virus-Infected Patients
ABSTRACT Filibuvir (PF-00868554) is an investigational nonnucleoside inhibitor of the hepatitis C virus (HCV) nonstructural 5B… 
2011
2011
Colony-forming assays reveal enhanced suppression of hepatitis C virus replication using combinations of direct-acting antivirals.
2011
2011
THE HEPATITIS C TREATMENT PIPELINE REPORT
BMS-650032 • BOCEPREVIR • CTS-1027 • DANOPREVIR • GS 9256 GS 9451 • IDX 320 • MK-5172 • TELAPREVIR • TMC435350 • VANIPREVIR VX… 
2010
2010
Gateways to clinical trials.
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the… 
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