Gateways to clinical trials.

  title={Gateways to clinical trials.},
  author={A. Tomillero and M. A. Moral},
  journal={Methods and findings in experimental and clinical pharmacology},
  volume={32 9},
Gateways to Clinical Trials is a guide to the most recent clinical trials in current literature and congresses. The data in the following tables has been retrieved from the Clinical Trials Knowledge Area of Thomson Reuters Integrity(SM), the drug discovery and development portal, This issue focuses on the following selection of drugs: Abatacept, Adalimumab, AdCD40L, Adefovir, Aleglitazar, Aliskiren fumarate, AM-103, Aminolevulinic acid methyl ester… Expand
Histone deacetylase inhibitors and pancreatic cancer: are there any promising clinical trials?
Clinical data for HDACIs in patients with pancreatic cancer are inadequate, because only a few studies have included patients suffering from this type of neoplasm and the number of Pancreatic cancer patients that entered HDACI phase II/III trials, among others with advanced solid tumors, is very limited. Expand
Interactions of Enhanced Urocortin 2 and Mineralocorticoid Receptor Antagonism in Experimental Heart Failure
A favorable profile of effects is demonstrated with short-term adjunct Ucn2 therapy and an MRA in HF, which further improved hemodynamics relative to that achieved by CA alone, while also reducing plasma renin activity, angiotensin II, aldosterone and vasopressin levels, and enhancing renal function. Expand
Catheterized guinea pigs infected with Ebola Zaire virus allows safer sequential sampling to determine the pharmacokinetic profile of a phosphatidylserine-targeting monoclonal antibody.
Using the guinea pig model of Ebola virus infection, a catheterized system was used which had the benefits of allowing repeated sampling of the same cohort of animals, and also a reduction in the use of sharps at high biological containment. Expand
Molecular biology of androgen-independent prostate cancer: the role of the androgen receptor pathway
There is evidence that these tumours that are considered castration-resistant continue to depend on AR signalling, and a number of novel agents targeting the AR signalling pathway under development, including more effective antiandrogens are under development. Expand
New Frontiers in Treatment
Patients experiencing advanced stage castration-resistant prostate cancer (CRPC) are at increased risk of developing skeletal-related events, including pathologic fractures and spinal cord compression. Expand
Dérivés de pyridopyrimidine en tant qu'inhibiteurs de protéine kinase
L'invention concerne des composes de Formule (I) dans lesquels R, R 1 et R 2 ont les significations indiquees dans la Revendication 1, qui sont des inhibiteurs de Syk, et peuvent etre utilises, entreExpand
Новые возможности наружной терапии тяжело протекающих форм атопического дерматита у детей
Повышение эффективности топического воздействия при атопическом дерматите у детей, а также поиск новых безопасных наружных средств является одной из актуальных задач современной дерматологии.Expand