estradiol 17-beta-dehydrogenase activity

Known as: 17beta-HSD, estradiol dehydrogenase activity, estrogen 17-oxidoreductase activity 
Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+. [EC:1.1.1.62]
National Institutes of Health

Topic mentions per year

Topic mentions per year

1967-2015
010203019672015

Related topics

Related topics

2 relations
3 (or 17)-beta-hydroxysteroid dehydrogenaseEstradiol 17 beta-Dehydrogenase

Related mentions per year

Related mentions per year

1967-2018
1960198020002020
estradiol 17-beta-dehydrogenase activity
Estradiol 17 beta-Dehydrogenase
3 (or 17)-beta-hydroxysteroid dehydrogenase

Papers overview

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2008
2008
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…
Aldo-keto reductase (AKR) 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase) regulates ligand access to… (More)
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2007
2007
Estrogen metabolizing enzymes in endometrium and endometriosis.
BACKGROUND Estradiol (E(2)) is an important promoter of the growth of both eutopic and ectopic endometrium. The findings with… (More)
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Highly Cited
2006
Highly Cited
2006
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
A novel 17beta-hydroxysteroid dehydrogenase (17beta-HSD) chronologically named type 12 17beta-HSD (17beta-HSD12), that transforms… (More)
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Highly Cited
2005
Highly Cited
2005
Mammalian lignans and genistein decrease the activities of aromatase and 17beta-hydroxysteroid dehydrogenase in MCF-7 cells.
Estrogen plays a major role in breast cancer development and progression. Breast tissue and cell lines contain the necessary… (More)
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2001
2001
Abnormal expression of 17beta-hydroxysteroid dehydrogenases in breast cancer predicts late recurrence.
The 17beta-hydroxysteroid dehydrogenase (17beta-HSD) enzymes are involved in the interconversion of biologically active and… (More)
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1999
1999
Loss of estrogen inactivation in colonic cancer.
Age and sex differences in the incidence of colonic cancer, together with epidemiological data on patients taking hormone… (More)
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1999
1999
Immunocytochemical localization of type 5 17beta-hydroxysteroid dehydrogenase in human reproductive tissues.
17beta-hydroxysteroid dehydrogenase (17beta-HSD) controls the last step in the formation of all androgens and all estrogens. At… (More)
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1999
1999
Determination of cDNA, gene structure and chromosomal localization of the novel human 17beta-hydroxysteroid dehydrogenase type 7(1).
We have identified human 17beta-hydroxysteroid dehydrogenase type 7 (17beta-HSD 7). The novel human cDNA encodes a 37 kDa protein… (More)
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1981
1981
Effects of estrogens and progestins on the biochemistry and morphology of the postmenopausal endometrium.
To study the effects of exogenous estrogens on the postmenopausal endometrium, and to determine the time course and minimum… (More)
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Highly Cited
1975
Highly Cited
1975
Induction of human endometrial estradiol dehydrogenase by progestins.
Estradiol-17beta dehydrogenase activity in proliferative human endometrium (average of 1.5 nmole of estrone formed from estradiol… (More)
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