establishment of spindle orientation

Disrupting LGN’s function at lateral membrane domains displaces the axis of cell division in cyst-forming MDCK cells. 

BACKGROUND Formation of epithelial sheets requires that cell division occurs in the plane of the sheet. During mitosis, spindle… Expand

Asymmetric cell division is intensely studied because it can generate cellular diversity as well as maintain stem cell… Expand

The establishment of apical–basal polarity within a single cell and throughout a growing tissue is a key feature of epithelial… Expand

Mitotic spindle orientation and plane of cleavage in mammals is a determinant of whether division yields progenitor expansion and… Expand

During asymmetric cell division, the mitotic spindle must be properly oriented to ensure the asymmetric segregation of cell fate… Expand

Asymmetric cell division generates cell diversity during development and regulates stem-cell self-renewal in Drosophila and… Expand

BackgroundThe choice of a stem cell to divide symmetrically or asymmetrically has profound consequences for development and… Expand

Microtubules and actin filaments interact and cooperate in many processes in eukaryotic cells, but the functional implications of… Expand

Localization of dynein–green fluorescent protein (GFP) to cytoplasmic microtubules allowed us to obtain one of the first views of… Expand