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epoxomicin

Known as: L-threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-L-threoninamide 
National Institutes of Health

Related topics

Related topics

2 relations

Broader (2)

OligopeptidesProteasome inhibitor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
From epoxomicin to carfilzomib: chemistry, biology, and medical outcomes.
  • K. KimC. Crews
  • Natural product reports (Print)
  • 2013
  • Corpus ID: 26026109
The initial enthusiasm following the discovery of a pharmacologically active natural product is often fleeting due to the poor… 
Highly Cited
2011
Highly Cited
2011
A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue.
Highly Cited
2010
Highly Cited
2010
Activity-based profiling reveals reactivity of the murine thymoproteasome-specific subunit beta5t.
Highly Cited
2010
Highly Cited
2010
sAPPα antagonizes dendritic degeneration and neuron death triggered by proteasomal stress
Highly Cited
2009
Highly Cited
2009
The Proteasome Inhibitor Epoxomicin Has Potent Plasmodium falciparum Gametocytocidal Activity
ABSTRACT Malaria continues to be a major global health problem, but only a limited arsenal of effective drugs is available. None… 
2008
2008
Mammalian 26S Proteasomes Remain Intact during Protein Degradation
Highly Cited
2003
Highly Cited
2003
Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro.
We have found that the ubiquitin-proteasome pathway exerts exquisite control of osteoblast differentiation and bone formation in… 
Highly Cited
1992
Highly Cited
1992
Epoxomicin, a new antitumor agent of microbial origin.
An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16… 
Highly Cited
1991
Highly Cited
1991
Novel epoxysuccinyl peptides Selective inhibitors of cathepsin B, in vitro
Highly Cited
1981
Highly Cited
1981
Primary structure of corticotropin-releasing factor from ovine hypothalamus.
Sequence analysis was performed of an ovine hypothalamic 41-residue polypeptide that had been postulated to be a putative… 
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