epoxomicin

Known as: L-threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-L-threoninamide 
 
National Institutes of Health

Papers overview

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Review
2013
Review
2013
The initial enthusiasm following the discovery of a pharmacologically active natural product is often fleeting due to the poor… (More)
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Highly Cited
2010
Highly Cited
2010
Fungal and oomycete plant pathogens translocate effector proteins into host cells to establish infection. However, virulence… (More)
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Highly Cited
2009
Highly Cited
2009
measure epoxomicin uptake we utilized another P-gP substrate to determine if drug efflux is altered in KMS11R cells. Doxorubicin… (More)
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Highly Cited
2007
Highly Cited
2007
The proteasome has emerged as an important target for cancer therapy with the approval of bortezomib, a first-in-class… (More)
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Highly Cited
2004
Highly Cited
2004
Environmental toxins have been implicated in the etiology of Parkinson's disease. Recent findings of defects in the ubiquitin… (More)
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Highly Cited
2003
Highly Cited
2003
Parkin gene mutations have been implicated in autosomal-recessive early-onset parkinsonism and lead to specific degeneration of… (More)
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Highly Cited
2002
Highly Cited
2002
Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and… (More)
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Highly Cited
1999
Highly Cited
1999
The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show… (More)
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Highly Cited
1992
Highly Cited
1992
An actinomycete strain No. Q996-17 produced a novel compound, epoxomicin, which exhibited in vivo antitumor activity against B16… (More)
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Highly Cited
1991
Highly Cited
1991
A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these… (More)
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