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epoxomicin

Known as: L-threoninamide, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-, N-acetyl-N-methyl-L-isoleucyl-L-isoleucyl-N-((1S)-3-methyl-1-(((2R)-2-methyl-2-oxiranyl)carbonyl)butyl)-L-threoninamide 
 
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
The proteasome has emerged as an important target for cancer therapy with the approval of bortezomib, a first-in-class… Expand
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Review
2005
Review
2005
The sole application of an inhibitor of the dipeptidyl peptidase DP IV (also DP 4, CD26, DPP-IV or DPP-4) to a mammal… Expand
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Highly Cited
2004
Highly Cited
2004
Environmental toxins have been implicated in the etiology of Parkinson's disease. Recent findings of defects in the ubiquitin… Expand
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Highly Cited
2003
Highly Cited
2003
Parkin gene mutations have been implicated in autosomal-recessive early-onset parkinsonism and lead to specific degeneration of… Expand
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Highly Cited
2002
Highly Cited
2002
Protein conformational disorders (PCDs), such as Alzheimer's disease, Huntington's disease (HD), Parkinson's disease and… Expand
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Highly Cited
2002
Highly Cited
2002
Many normal human cells produce thrombospondin‐1 (TSP‐1), a potent antiangiogenic protein that promotes vascular quiescence. In… Expand
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Highly Cited
1999
Highly Cited
1999
The proteasome regulates cellular processes as diverse as cell cycle progression and NF-kappaB activation. In this study, we show… Expand
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Highly Cited
1999
Highly Cited
1999
Epoxomicin (1), a peptide alpha',beta'-epoxyketone isolated from the actinomycete strain No.Q996-17, possesses potent in vivo… Expand
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Highly Cited
1991
Highly Cited
1991
A series of new epoxysuccinyl peptides were designed and synthesized to develop a specific inhibitor of cathepsin B. Of these… Expand
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Highly Cited
1981
Highly Cited
1981
Sequence analysis was performed of an ovine hypothalamic 41-residue polypeptide that had been postulated to be a putative… Expand
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