epithelial tube branching involved in lung morphogenesis
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Significance Human mutations in SOX9 lead to several congenital disorders, including campomelic dysplasia. Babies born with this… Expand Somatic activation of Ras occurs frequently in human cancers, including one-third of lung cancers. Activating Ras mutations also… Expand Experimental evidence is rapidly emerging that the coupling of positive regulatory signals with the induction of negative… Expand Development of the mouse lung initiates on day 9.5 postcoitum from the laryngotracheal groove and involves mesenchymal-epithelial… Expand In Drosophila embryos, the loss of sprouty gene function enhances branching of the respiratory system. Three human sprouty… Expand Fibroblast growth factor (FGF) signaling is required for normal epithelial branching in the respiratory system of several species… Expand The mammalian lung develops through branching morphogenesis which is controlled by growth factors, hormones, and extracellular… Expand Lung buds isolated from 11.5 days post coitum mouse embryos survive and undergo branching morphogenesis in culture. This organ… Expand A major unsolved problem in developmental biology is to determine when and how time- and position-restricted instructions are… Expand We recently found that polyclonal antibodies to laminin, a basement membrane-related glycoprotein, inhibited murine lung… Expand