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epiroprim

A trimethoprim analogue and selective inhibitor of microbial dihydrofolate reductase, with antibacterial activity. Epiroprim inhibits the bacterial… Expand
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
The objective of this study was to use in synergy physiologically based and empirical approaches to estimate the drug-specific… Expand
2002
2002
  • A. M. Dhople
  • International journal of antimicrobial agents
  • 2002
  • Corpus ID: 22694042
The antimicrobial effects of a new dihydrofolate reductase inhibitor, epiroprim, either singly or in combination with dapsone… Expand
2001
2001
Thirty Mycobacterium tuberculosis strains (8: INH<sup>R</sup>/INH<sup>R</sup>, 12: INH<sup>R</sup>/RIF<sup>S</sup>, 10: INH<sup>S… Expand
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1999
1999
The antimicrobial effects of a new dihydrofolate reductase inhibitor, epiroprim, alone and in combination with dapsone and… Expand
1999
1999
  • A. M. Dhople
  • International journal of antimicrobial agents
  • 1999
  • Corpus ID: 7010412
The antimicrobial effects of a new dihydrofolate reductase inhibitor, epiroprim, alone and in combination with dapsone and… Expand
1997
1997
Congenitally immunodeficient and immunosuppressed normal mice with naturally acquired Pneumocystis carinii infection were… Expand
1996
1996
Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity… Expand
1996
1996
In a rat model of dual infection, we studied such dihydrofolate reductase (DHFR) inhibitors as PS-15 (25 mg/kg of body weight… Expand
1996
1996
Toxoplasma gondii is a major cause of focal encephalitis in patients with acquired immunodeficiency syndrome. Epiroprim, an… Expand
1994
1994
We examined the effect of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone… Expand