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epiroprim

A trimethoprim analogue and selective inhibitor of microbial dihydrofolate reductase, with antibacterial activity. Epiroprim inhibits the bacterial… 
National Institutes of Health

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Broader (1)

Trimethoprim
analogs & derivatives

Papers overview

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2002
2002
Interaction Energy Analysis of Nonclassical Antifolates with Pneumocystis carinii Dihydrofolate Reductase
Abstract: The x-ray structure of the Pneumocystis carinii dihydrofolate reductase (DHFR):trimethoprim:NADPH ternary complex… 
2002
2002
In vivo activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with dapsone, against Mycobacterium leprae.
2002
2002
[Preliminary study on isoniazid-epiroprim combination in a tuberculosis murine model].
The purpose of this study regarding isoniazid-epiroprim's association applied to antituberculosis chemotherapy, carried through… 
2001
2001
Experimental in vitro Efficacy Study on the Interaction of Epiroprim plus Isoniazid against Mycobacterium tuberculosis
Thirty Mycobacterium tuberculosis strains (8: INH<sup>R</sup>/INH<sup>R</sup>, 12: INH<sup>R</sup>/RIF<sup>S</sup>, 10: INH<sup>S… 
1999
1999
In vitro activity of epiroprim, a dihydrofolate reductase inhibitor, singly and in combination with brodimoprim and dapsone, against Mycobacterium leprae
Highly Cited
1996
Highly Cited
1996
Antibacterial activities of epiroprim, a new dihydrofolate reductase inhibitor, alone and in combination with dapsone
Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity… 
1996
1996
Efficacy of epiroprim (Ro11-8958), a new dihydrofolate reductase inhibitor, in the treatment of acute Toxoplasma infection in mice.
Toxoplasma gondii is a major cause of focal encephalitis in patients with acquired immunodeficiency syndrome. Epiroprim, an… 
1996
1996
Simple HPLC Determination of the Concentrations of Epiroprim in the Serum and Brains of Mice
Epiroprim, an analogue of trimethoprim, has been shown to potentiate the efficacy of dapsone in experimental parasitic infections… 
1994
1994
Activity of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone against Toxoplasma gondii
We examined the effect of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone… 
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