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epiroprim

A trimethoprim analogue and selective inhibitor of microbial dihydrofolate reductase, with antibacterial activity. Epiroprim inhibits the bacterial… Expand
National Institutes of Health

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2013
2013
We developed a hybrid method for predicting plasma concentration-time curves in humans by integrating species differences in in… Expand
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2004
2004
The new bacteriocidal drug epiroprim (Ro-11-8958) was tested (alone or in combination with dapsone) on its efficacy… Expand
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Highly Cited
2003
Highly Cited
2003
The objective of this study was to use in synergy physiologically based and empirical approaches to estimate the drug-specific… Expand
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2002
2002
  • Arvind M. Dhople
  • International journal of antimicrobial agents
  • 2002
  • Corpus ID: 22694042
The antimicrobial effects of a new dihydrofolate reductase inhibitor, epiroprim, either singly or in combination with dapsone… Expand
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2002
2002
Abstract: The x-ray structure of the Pneumocystis carinii dihydrofolate reductase (DHFR):trimethoprim:NADPH ternary complex… Expand
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2001
2001
Thirty Mycobacterium tuberculosis strains (8: INH<sup>R</sup>/INH<sup>R</sup>, 12: INH<sup>R</sup>/RIF<sup>S</sup>, 10: INH<sup>S… Expand
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1999
1999
  • Arvind M. Dhople
  • International journal of antimicrobial agents
  • 1999
  • Corpus ID: 7010412
The antimicrobial effects of a new dihydrofolate reductase inhibitor, epiroprim, alone and in combination with dapsone and… Expand
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1996
1996
Epiroprim (EPM; Ro 11-8958) is a new selective inhibitor of microbial dihydrofolate reductase. EPM displayed excellent activity… Expand
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1996
1996
In a rat model of dual infection, we studied such dihydrofolate reductase (DHFR) inhibitors as PS-15 (25 mg/kg of body weight… Expand
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1994
1994
We examined the effect of epiroprim (Ro 11-8958), a dihydrofolate reductase inhibitor, alone and in combination with dapsone… Expand
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