Semantic Scholar uses AI to extract papers important to this topic.
The mechanisms by which MAP kinases recognize and phosphorylate substrates are not completely understood. Efforts to understand… Expand Triosephosphate isomerase (TIM) is a perfectly evolved enzyme which very fast interconverts dihydroxyacetone phosphate and d… Expand Summary Regulation and maximization of lipase production in a mutant derivative of R. oligosporus has been investigated using… Expand Infra red spectroscopy has been used experimentally for many years to probe enzyme reaction intermediates. Our interests lie in… Expand We have prepared a series of undecadeoxynudeotides that contain changes in the functional group pattern present within the EcoRV… Expand The mechanism of action of inosine-uridine nucleoside hydrolase has been investigated by long-term molecular dynamics (MD… Expand The origin of the catalytic power of enzymes is discussed, paying attention to evolutionary constraints. It is pointed out that… Expand The detailed molecular dynamics of an actual bond-breaking event in a fluctuating enzyme substrate complex is simulated. The… Expand Publisher Summary The ATP molecule contains three distinct structural groupings: the adenine base, the ribose sugar, and the… Expand A simple derivation is given that the catalytic term kcat/KS is at a maximum when the structure of the enzyme is complementary to… Expand