englerin A
National Institutes of Health
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Renal cell carcinoma (RCC) is among the top ten most common forms of cancer and is the leading malignancy of the kidney. Clear…
Englerin A, a guaiane sesquiterpene isolated from Phyllanthus engleri, showed highly potent and selective growth inhibitory…
High-throughput screening of extracts from plants, marine, and micro-organisms led to the identification of the extract from the…
A practical synthesis of (–)-englerin A was accomplished in 17 steps and 11% global yield from commercially available achiral…
Racemic 4-demethylenglerin A (1′), a simplified analog of the guaiane-type sesquiterpene englerin A (1), has been synthesized…
The chlorinated englerins (3-9) were isolated from Phyllanthus engleri and shown to selectively inhibit the growth of renal…
Abstract Englerin A is an oxo-bridged guaiane-type sesquiterpenoid isolated from Phyllanthus engleri, and displays potent and…
An effective total synthesis of (-)-9-deoxy-englerin (4), an analogue of the natural guaiane sesquiterpene englerin A (1), has…
Background: Englerin A (EA) is a natural product which has shown selective toxicity toward kidney tumor cells in the NCI60 panel…
Introduction and Objectives: The Natural Products Branch of the National Cancer Institute examined extracts from a number of…