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emtansine

Known as: DM1 compound 
National Institutes of Health

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Broader (1)

Maytansine
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Comparison of outcomes in a population-based cohort of women with metastatic breast cancer receiving anti-HER2 therapy with clinical trial outcomes.
1037 Background: Little data exist for comparing cardiac safety and survival outcomes of anti-HER2 therapy with concurrent… 
2018
2018
Natural Products from Australian Celastraceae Plants and Their Leucine Transport Inhibition in Prostate Cancer Cells
Natural products are the main source of approved medicines with more than half of the drugs on the market today being either… 
2017
2017
Poster 433: Receptor-antibody clustering induced endocytosis of HER2 has therapeutic potential in breast cancer
BACKGROUND: HER2 is an oncogenic receptor, promoting tumour development and disease progression in 15-25% of breast cancers. HER2… 
2017
2017
Central validation of HER2 status to determine heterogeneity of marker expression in HER2-positive gastric cancer (GC).
12Background: 10-20% of GC overexpress HER2, a membrane-bound receptor tyrosine kinase (RTK) which belongs to the epidermal… 
2014
2014
Télangiectasies cutanéo-muqueuses diffuses induites par l’anticorps conjugué TDM-1
2013
2013
Fifteen years of anti-HER2 therapy.
Last month brought the accelerated approval by the US Food and Drug Administration (FDA) of a fourth agent targeting the human… 
2011
2011
P1-12-07: Pharmacokinetics (PK) of Trastuzumab Emtansine and Paclitaxel or Docetaxel in Patients with HER2−Positive MBC Previously Treated with a Trastuzumab-Containing Regimen.
Background: Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate composed of trastuzumab, DM1 (a potent cytotoxic tubulin… 
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