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elesclomol
Known as:
1-N'-benzenecarbothioyl-3-(2-benzenecarbothioyl-2-methylhydrazinyl)-N'-methyl- oxopropanehydrazidide
, Propanedioic Acid, Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]
A small-molecule bis(thio-hydrazide amide) with oxidative stress induction, pro-apoptotic, and potential antineoplastic activities. Elesclomol…
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National Institutes of Health
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Related topics
Related topics
4 relations
Elesclomol Sodium
NCIt Antineoplastic Agent Terminology
Broader (1)
Hydrazines
Narrower (1)
STA-4783
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Elesclomol rescues Menkes disease mice
S. Hurtley
2020
Corpus ID: 218934427
Biomedicine Menkes disease results from loss-of-function mutations in the P-type copper-transporting adenosine triphosphatase…
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2016
2016
Abstract B20: In silico and in vitro drug screening identifies new therapeutic approaches targeting DNA double-strand breaks repair in Ewing sarcoma
Yan Ma
,
Bin Chen
,
S. Weir
,
A. Butte
,
A. Godwin
2016
Corpus ID: 88783922
Purpose: Ewing sarcoma (EWS) is the second most frequent malignant bone and soft-tissue tumor in children and young adults. More…
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2015
2015
Redox modulation of oxidatively induced DNA damage by ascorbate enhances melanoma cancer cell DNA damage formation & cell killing
H. Najeeb
2015
Corpus ID: 85661365
Redox modulation of oxidatively induced DNA damage by ascorbate enhances melanoma cancer cell DNA damage formation & cell killing…
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Review
2012
Review
2012
Title: The Relationship of Thioredoxin-1 and Cisplatin Resistance: Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells Running Title: The impact of TRX1 on ROS and oxidative metabolism
M. Wangpaichitr
,
G. Theodoropoulos
,
+5 authors
N. Savaraj
2012
Corpus ID: 862843
Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Elimination of…
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2012
2012
Therapeutic Discovery The Relationship of Thioredoxin-1 and Cisplatin Resistance : Its Impact on ROS and Oxidative Metabolism in Lung Cancer Cells
M. Wangpaichitr
,
E. Sullivan
,
+6 authors
N. Savaraj
2012
Corpus ID: 36046518
Elimination of cisplatin-resistant lung cancer cells remains a major obstacle. We have shown that cisplatinresistant…
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2009
2009
Elesclomol trials suspended because of safety concerns
F. Staff
2009
Corpus ID: 79028233
Synta Pharmaceuticals and GlaxoSmithKline have announced that they are suspending a phase 3 trial of elesclomol in chemotherapy…
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2009
2009
Gateways to clinical trials.
A. Tomillero
,
M. A. Moral
Methods and Findings in Experimental and Clinical…
2009
Corpus ID: 12057384
(-)-Gossypol; Abacavir sulfate/lamivudine, ACAM-1000, ACE-011, Agomelatine, AGS-004, Alemtuzumab, Alvocidib hydrochloride, AMG…
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2008
2008
Elesclomol (formerly STA-4783) induces oxidative stress selectively in cancer cells and inhibits tumor growth independent of immune status
J. Bertin
,
Irma Allen
,
+20 authors
K. Foley
2008
Corpus ID: 58152887
3300 Background: Elesclomol (formerly STA-4783) is a novel, small molecule investigational drug candidate that stimulates…
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2008
2008
Apoptosis inducer hits melanoma with double whammy
C. Helwick
2008
Corpus ID: 181788348
STOCKHOLM—Elesclomol, an investigational small-molecule oxidative stress inducer (Synta Pharmaceuticals), in combination with…
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2008
2008
Elesclomol enhances efficacy of paclitaxel for melanoma
2008
Corpus ID: 195121155