STA-4783

LPS and heat stress have been shown to exert various toxic effects in animals, as they induce estradiol biosynthesis dysfunction… Expand

Small-molecule inhibitors of the phosphoinositide 3-kinase (PI3K), Akt, and mTOR pathway currently in the clinic produce a… Expand

Targeted biologic therapies such as anti-cytotoxic T lymphocyte antigen (CTLA-4) monoclonal antibodies, either as monotherapy or… Expand

14595 Background: Elesclomol is a novel small-molecule oxidative stress inducer known to synergize with taxanes and certain other… Expand

PURPOSE STA-4783 is a new compound that markedly enhances the therapeutic index of paclitaxel against human tumor xenograft… Expand

B274 Background: STA-4783 is a novel small molecule that induces oxidative stress in cancer cells. It is being evaluated in… Expand

14107 Background: STA-4783 is an inducer of Hsp70 expression and apoptosis that recently completed a successful Phase II clinical… Expand

Purpose: STA-4783 is a new compound that markedly enhances the therapeutic index of paclitaxel against human tumor xenograft… Expand

The apoptosis stimulator STA-4783 acts by inducing expression of heat shock protein (Hsp)70 on tumor cell surfaces and disrupting… Expand

7561 Background: STA-4783 (S), a novel inducer of heat shock protein 70 (hsp70) is a bis-thiobenzoylhydrazide compound. S leads… Expand