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STA-4783

Known as: STA 4783, STA4783 
National Institutes of Health

Related topics

Related topics

2 relations
Elesclomol Sodium

Broader (1)

elesclomol

Papers overview

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2017
2017
Lipopolysaccharide and heat stress impair the estradiol biosynthesis in granulosa cells via increase of HSP70 and inhibition of smad3 phosphorylation and nuclear translocation.
Review
2015
Review
2015
Molecular Pathways: Mitochondrial Reprogramming in Tumor Progression and Therapy
Small-molecule inhibitors of the phosphoinositide 3-kinase (PI3K), Akt, and mTOR pathway currently in the clinic produce a… 
2013
2013
Syntheses and antitumor activities of N'1,N'3-dialkyl-N'1,N'3-di-(alkylcarbonothioyl) malonohydrazide: the discovery of elesclomol.
Review
2008
Review
2008
Overcoming immunologic tolerance to melanoma: targeting CTLA-4 with ipilimumab (MDX-010).
  • J. Weber
  • The oncologist
  • 2008
  • Corpus ID: 8023402
Targeted biologic therapies such as anti-cytotoxic T lymphocyte antigen (CTLA-4) monoclonal antibodies, either as monotherapy or… 
2008
2008
Integrated safety analysis of elesclomol (formerly STA-4783) co-administered with paclitaxel
14595 Background: Elesclomol is a novel small-molecule oxidative stress inducer known to synergize with taxanes and certain other… 
2007
2007
Phase I Clinical Trial of STA-4783 in Combination with Paclitaxel in Patients with Refractory Solid Tumors
Purpose: STA-4783 is a new compound that markedly enhances the therapeutic index of paclitaxel against human tumor xenograft… 
2006
2006
Drug evaluation: STA-4783--enhancing taxane efficacy by induction of Hsp70.
  • M. Gehrmann
  • Current opinion in investigational drugs
  • 2006
  • Corpus ID: 8362147
The apoptosis stimulator STA-4783 acts by inducing expression of heat shock protein (Hsp)70 on tumor cell surfaces and disrupting… 
2005
2005
A phase 1/2 study of STA-4783 in combination with paclitaxel and carboplatin in chemo-naive advanced non-small cell lung cancer (NSCLC)
7106 Background: STA-4783 (S) is a bis-thiobenzoylhydrazide that induces heat shock protein 70 (hsp 70). S significantly enhanced… 
2005
2005
A 2-stage controlled phase 1/2 study of STA-4783 in combination with paclitaxel in patients with advanced metastatic melanoma
7561 Background: STA-4783 (S), a novel inducer of heat shock protein 70 (hsp70) is a bis-thiobenzoylhydrazide compound. S leads… 
2004
2004
STA-4783, a novel HSP inducer, enhances paclitaxel activity-Preclinical to clinical modeling.
3124 Background: STA-4783 is a newly synthesized bis-thiobenzoylhydrazide (MW 400) that promotes tumor-specific induction of heat… 
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