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elastase inhibitor

 
National Institutes of Health

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Highly Cited
2012
Highly Cited
2012
Neutrophil elastase plays pivotal roles in the pathogenesis of pulmonary fibrosis. The neutrophil elastase inhibitor, sivelestat… Expand
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2011
2011
INTRODUCTION Sivelestat, a neutrophil elastase inhibitor, has been approved in Japan for the treatment of patients with acute… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Increased serine elastase activity has been implicated in the vascular remodeling associated with chronic hypoxia… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Peripheral blood mononuclear cells (PBMNCs), platelets, and polymorphonuclear leukocytes (PMNs) contain various… Expand
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Highly Cited
2002
Highly Cited
2002
To test whether a serine elastase inhibitor could prevent or reduce emphysema, we exposed guinea pigs to cigarette smoke acutely… Expand
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Highly Cited
2000
Highly Cited
2000
Progression of pulmonary hypertension is associated with increased serine elastase activity and the proteinase-dependent… Expand
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Highly Cited
1998
Highly Cited
1998
Intestinal ischemia-reperfusion (I-R) is associated with lung injury and the acute respiratory distress syndrome. The hypothesis… Expand
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Highly Cited
1998
Highly Cited
1998
Intestinal ischemia-reperfusion (I-R) is associated with lung injury and the acute respiratory distress syndrome. The hypothesis… Expand
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Highly Cited
1996
Highly Cited
1996
We investigated the effect of activated protein C (APC) on lipopolysaccharide (LPS)-induced pulmonary vascular injury in rats to… Expand
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Highly Cited
1992
Highly Cited
1992
Inhibitors of human neutrophil elastase were engineered by designing and producing a library of phage-displayed protease… Expand
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