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efavirenz

Known as: (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, (S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one, efavirenz, (S)-isomer 
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus… 
National Institutes of Health

Related topics

Related topics

24 relations
Acquired Immunodeficiency SyndromeCYP2B6 protein, humanDrug AllergyEfavirenz:ACnc:Pt:Ser/Plas:Qn

Broader (7)

Antiviral AgentsBenzoxazinesCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2C9 Inhibitors

Narrower (5)

AtriplaDMP 266L 743726Stocrin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Pharmacogenetics‐Based Population Pharmacokinetic Analysis of Efavirenz in HIV‐1‐Infected Individuals
Besides CYP2B6, other polymorphic enzymes contribute to efavirenz (EFV) interindividual variability. This study was aimed at… 
Highly Cited
2009
Highly Cited
2009
Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine
The non-nucleoside reverse transcriptase inhibitor efavirenz (EFV) is directly conjugated by the UDP-glucuronosyltransferase (UGT… 
Highly Cited
2008
Highly Cited
2008
A 96-week comparison of lopinavir-ritonavir combination therapy followed by lopinavir-ritonavir monotherapy versus efavirenz combination therapy.
Antiretroviral-naive HIV-1-infected volunteers received zidovudine/lamivudine plus either lopinavir/ritonavir (n=104) or… 
Highly Cited
2005
Highly Cited
2005
6-[1-(4-Fluorophenyl)methyl-1H-pyrrol-2-yl)]-2,4-dioxo-5-hexenoic acid ethyl ester a novel diketo acid derivative which selectively inhibits the HIV-1 viral replication in cell culture and the…
Highly Cited
2004
Highly Cited
2004
Abacavir versus zidovudine combined with lamivudine and efavirenz, for the treatment of antiretroviral-naive HIV-infected adults.
BACKGROUND Zidovudine, lamivudine, and efavirenz comprise a highly effective and well-tolerated triple regimen for antiretroviral… 
Highly Cited
2004
Highly Cited
2004
Efavirenz Plasma Concentrations in HIV-Infected Patients: Inter- and Intraindividual Variability and Clinical Effects
Efavirenz is a drug subject to extensive metabolism, mainly by the cytochrome P-450 isoenzyme CYP2B6, known to exhibit extensive… 
Highly Cited
2003
Highly Cited
2003
Long‐term assessment of neuropsychiatric adverse reactions associated with efavirenz
The Sensio study objectives were to assess the outcome of neuropsychiatric adverse reactions (NPAR) that develop after initiation… 
Highly Cited
2003
Highly Cited
2003
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Highly Cited
2001
Highly Cited
2001
Ritonavir, efavirenz, and nelfinavir inhibit CYP2B6 activity in vitro: potential drug interactions with bupropion.
Since antiretroviral drugs are known to inhibit many cytochrome P450 isoforms, the inhibition of CYP2B6 by non-nucleoside reverse… 
Highly Cited
2000
Highly Cited
2000
Isolation and Characterization of an Equine Foamy Virus
ABSTRACT Foamy viruses (FVs) are complex retroviruses which have been isolated from different animal species including nonhuman… 
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