efavirenz

Known as: (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, (S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one, efavirenz, (S)-isomer 
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
BACKGROUND Efavirenz with tenofovir-disoproxil-fumarate and emtricitabine is a preferred antiretroviral regimen for treatment… (More)
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Highly Cited
2011
Highly Cited
2011
BACKGROUND The non-nucleoside reverse transcriptase inhibitor (NNRTI), rilpivirine (TMC278; Tibotec Pharmaceuticals, County Cork… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND The MERIT (Maraviroc versus Efavirenz in Treatment-Naive Patients) study compared maraviroc and efavirenz, both with… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND Use of raltegravir with optimum background therapy is effective and well tolerated in treatment-experienced patients… (More)
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Highly Cited
2004
Highly Cited
2004
OBJECTIVES Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and population… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The 2NN Study was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine… (More)
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Highly Cited
2003
Highly Cited
2003
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to identify the routes of efavirenz metabolism and… (More)
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Highly Cited
2001
Highly Cited
2001
OBJECTIVE Limited information exists on the clinical usefulness of drug level monitoring for efavirenz, a once-daily non… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Efavirenz is a nonnucleoside reverse-transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). We… (More)
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