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efavirenz
Known as:
(S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one
, (S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one
, efavirenz, (S)-isomer
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A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus…
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National Institutes of Health
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Related topics
Related topics
24 relations
Acquired Immunodeficiency Syndrome
CYP2B6 protein, human
Drug Allergy
Efavirenz:ACnc:Pt:Ser/Plas:Qn
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Broader (7)
Antiviral Agents
Benzoxazines
Cytochrome P-450 CYP2B6 Inducers
Cytochrome P-450 CYP2C9 Inhibitors
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Narrower (5)
Atripla
DMP 266
L 743726
Stocrin
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2009
Highly Cited
2009
Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus.
K. Hancock
,
V. Veguilla
,
+11 authors
J. Katz
New England Journal of Medicine
2009
Corpus ID: 11416495
BACKGROUND A new pandemic influenza A (H1N1) virus has emerged, causing illness globally, primarily in younger age groups. To…
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Review
2008
Review
2008
Antiretroviral Treatment of Adult HIV Infection 2008 Recommendations of the International AIDS Society–USA Panel
S. Hammer
,
J. Eron
,
+10 authors
D. Richman
2008
Corpus ID: 33568341
form at peer-reviewed sci-
Highly Cited
2006
Highly Cited
2006
Tenofovir DF, emtricitabine, and efavirenz vs. zidovudine, lamivudine, and efavirenz for HIV.
J. Gallant
,
E. Dejesus
,
+9 authors
A. Cheng
New England Journal of Medicine
2006
Corpus ID: 24037755
BACKGROUND Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well…
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Review
2005
Review
2005
British HIV Association guidelines for the treatment of HIV‐1‐infected adults with antiretroviral therapy 2008
B. Gazzard
HIV Medicine
2005
Corpus ID: 9431775
The 2008 BHIVA Guidelines have been updated to incorporate all the new relevant information (including presentations at the 15th…
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Highly Cited
2004
Highly Cited
2004
Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
D. Haas
,
H. Ribaudo
,
+7 authors
E. Acosta
AIDS (London)
2004
Corpus ID: 9410300
Objectives: Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and…
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Review
2004
Review
2004
Triple-nucleoside regimens versus efavirenz-containing regimens for the initial treatment of HIV-1 infection.
R. Gulick
,
H. Ribaudo
,
+13 authors
D. Kuritzkes
New England Journal of Medicine
2004
Corpus ID: 22253836
BACKGROUND Regimens containing three nucleoside reverse-transcriptase inhibitors offer an alternative to regimens containing…
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Highly Cited
2003
Highly Cited
2003
The Cytochrome P450 2B6 (CYP2B6) Is the Main Catalyst of Efavirenz Primary and Secondary Metabolism: Implication for HIV/AIDS Therapy and Utility of Efavirenz as a Substrate Marker of CYP2B6…
B. Ward
,
J. Gorski
,
David R. Jones
,
S. Hall
,
D. Flockhart
,
Z. Desta
Journal of Pharmacology and Experimental…
2003
Corpus ID: 15336462
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to identify the routes of efavirenz metabolism and…
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Highly Cited
2002
Highly Cited
2002
Hepatotoxicity associated with nevirapine or efavirenz‐containing antiretroviral therapy: Role of hepatitis C and B infections
M. Sulkowski
,
David L. Thomas
,
S. Mehta
,
R. Chaisson
,
R. Moore
Hepatology
2002
Corpus ID: 11228258
Hepatologists are frequently asked to evaluate human immunodeficiency virus (HIV)‐infected patients with abnormal liver enzymes…
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Highly Cited
2002
Highly Cited
2002
Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
J. Fellay
,
C. Marzolini
,
E. R. Meaden
,
D. Back
,
for the Swiss Hiv Cohort Study
The Lancet
2002
Corpus ID: 44023713
Highly Cited
1999
Highly Cited
1999
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus zidovudine and lamivudine in the treatment of HIV-1 infection in adults. Study 006 Team.
Schlomo Staszewski
,
J. Morales-Ramirez
,
+9 authors
N. Ruiz
New England Journal of Medicine
1999
Corpus ID: 39144001
BACKGROUND Efavirenz is a nonnucleoside reverse-transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). We…
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