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efavirenz

Known as: (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, (S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one, efavirenz, (S)-isomer 
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus… 
National Institutes of Health

Related topics

Related topics

24 relations
Acquired Immunodeficiency SyndromeCYP2B6 protein, humanDrug AllergyEfavirenz:ACnc:Pt:Ser/Plas:Qn

Broader (7)

Antiviral AgentsBenzoxazinesCytochrome P-450 CYP2B6 InducersCytochrome P-450 CYP2C9 Inhibitors

Narrower (5)

AtriplaDMP 266L 743726Stocrin

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Lipodystrophy and weight changes: data from the Swiss HIV Cohort Study, 2000–2006
Combination antiretroviral therapy (cART) is changing, and this may affect the type and occurrence of side effects. We examined… 
Highly Cited
2006
Highly Cited
2006
QSAR for non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Highly Cited
2005
Highly Cited
2005
Efavirenz levels and 24-week efficacy in HIV-infected patients with tuberculosis receiving highly active antiretroviral therapy and rifampicin
Background:Concomitant use of efavirenz and rifampicin is common for treatment of HIV and tuberculosis. Plasma efavirenz levels… 
Highly Cited
2005
Highly Cited
2005
Pharmacokinetic interactions between efavirenz and rifampicin in the treatment of HIV and tuberculosis: one size does not fit all
The concomitant treatment of HIV–tuberculosis co-infection is complicated by pharmacological interactions between drugs… 
Highly Cited
2003
Highly Cited
2003
Simultaneous determination of nine antiretroviral compounds in human plasma using liquid chromatography.
Highly Cited
2002
Highly Cited
2002
Simple rapid method for quantification of antiretrovirals by liquid chromatography-tandem mass-spectrometry.
Highly Cited
2002
Highly Cited
2002
The influence of efavirenz on the pharmacokinetics of a twice‐daily combination of indinavir and low‐dose ritonavir in healthy Volunteers
This study evaluated the effect of multiple‐dose efavirenz on the steady‐state pharmacokinetics of the combination of indinavir… 
Highly Cited
2002
Highly Cited
2002
Determination of lopinavir and nevirapine by high-performance liquid chromatography after solid-phase extraction: application for the assessment of their transplacental passage at delivery.
Highly Cited
2001
Highly Cited
2001
Phenotypic hypersusceptibility to non-nucleoside reverse transcriptase inhibitors in treatment-experienced HIV-infected patients: impact on virological response to efavirenz-based therapy
BackgroundEnhanced susceptibility to non-nucleoside reverse transcriptase inhibitors (NNRTI) was recently described in… 
Highly Cited
2000
Highly Cited
2000
The species-dependent metabolism of efavirenz produces a nephrotoxic glutathione conjugate in rats.
Efavirenz, a potent nonnucleoside reverse transcriptase inhibitor widely prescribed for the treatment of HIV infection, produces… 
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