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efavirenz

Known as: (S)-6-chloro-4-(Cyclopropylethynyl)-1,4-dihydro-4-(trifluoromethyl)-2H-3,1-benzoxazin-2-one, (S)-6-chloro-4-Cyclopropylethynyl-4-trifluoromethyl-1,4-dihydro-benzo[D][1,3]oxazin-2-one, efavirenz, (S)-isomer 
A synthetic non-nucleoside reverse transcriptase (RT) inhibitor with antiviral activity. Efavirenz binds directly to the human immunodeficiency virus… Expand
National Institutes of Health

Papers overview

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Highly Cited
2009
Highly Cited
2009
BACKGROUND Use of raltegravir with optimum background therapy is effective and well tolerated in treatment-experienced patients… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND A new pandemic influenza A (H1N1) virus has emerged, causing illness globally, primarily in younger age groups. To… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Durable suppression of replication of the human immunodeficiency virus (HIV) depends on the use of potent, well… Expand
Highly Cited
2004
Highly Cited
2004
Objectives: Efavirenz is an effective antiretroviral agent, but central nervous system side effects occur commonly, and… Expand
Highly Cited
2004
Highly Cited
2004
BACKGROUND The 2NN Study was a randomised comparison of the non-nucleoside reverse-transcriptase inhibitors (NNRTI) nevirapine… Expand
Highly Cited
2004
Highly Cited
2004
Efavirenz (EFV) is metabolized by cytochrome P450 2B6 (CYP2B6) in the liver. We analyzed the genotypes of CYP2B6 and their… Expand
Highly Cited
2003
Highly Cited
2003
We used human liver microsomes (HLMs) and recombinant cytochromes P450 (P450s) to identify the routes of efavirenz metabolism and… Expand
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Highly Cited
2002
Highly Cited
2002
Hepatologists are frequently asked to evaluate human immunodeficiency virus (HIV)‐infected patients with abnormal liver enzymes… Expand
Highly Cited
2001
Highly Cited
2001
ObjectiveLimited information exists on the clinical usefulness of drug level monitoring for efavirenz, a once-daily non… Expand
Highly Cited
1999
Highly Cited
1999
BACKGROUND Efavirenz is a nonnucleoside reverse-transcriptase inhibitor of human immunodeficiency virus type 1 (HIV-1). We… Expand