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efaroxan

Known as: 2-((2-ethyl-2,3-dihydrobenzofuran-2-yl))-2-imidazoline 
 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Adrenergic alpha-AntagonistsBenzofuransImidazoles

Narrower (1)

efaroxan hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats
CR4056 is a novel imidazoline‐2 (I2) ligand exhibiting potent analgesic activity in animal models of pain. In this study, we… Expand
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2012
2012
Dexmedetomidine protects against oxygen–glucose deprivation‐induced injury through the I2 imidazoline receptor‐PI3K/AKT pathway in rat C6 glioma cells
Objectives  To explore the protection and the mechanism of dexmedetomidine on the oxygen–glucose deprivation (OGD) insults in rat… Expand
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2010
2010
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP‐sensitive K+ channels
Background and purpose:  ATP‐sensitive potassium channels (KATP channels) in beta cells are a major target for insulinotropic… Expand
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Highly Cited
2005
Highly Cited
2005
Mechanisms involved in the antinociception caused by agmatine in mice
The present study examined the antinociceptive effects of agmatine in chemical behavioural models of pain. Agmatine (1-30 mg/kg… Expand
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2001
2001
Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.
Efaroxan, like several other imidazoline reagents, elicits a glucose-dependent increase in insulin secretion from pancreatic beta… Expand
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1998
1998
Efaroxan, an alpha‐2 antagonist, in the treatment of progressive supranuclear palsy
We have tested, in a prospective randomized, double‐blind, placebo‐controlled, crossover, 12‐week study, the effects of 2 mg… Expand
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Highly Cited
1994
Highly Cited
1994
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
The rostral ventrolateral medulla (RVLM) is the primary region maintaining vasomotor tone, and a site of action for central… Expand
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Highly Cited
1993
Highly Cited
1993
Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080
1 The imidazoline α2‐adrenoceptor antagonist, efaroxan, stimulates insulin secretion from rat isolated islets and antagonizes the… Expand
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Highly Cited
1993
Highly Cited
1993
Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site.
We have studied the stereospecificity of three responses mediated by the alpha 2-antagonist efaroxan in rat islets of Langerhans… Expand
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Highly Cited
1990
Highly Cited
1990
Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels.
The imidazoline alpha 2-antagonist efaroxan was found to stimulate insulin secretion from isolated rat pancreatic islets… Expand
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