eculizumab

Known as: Immunoglobulin, Anti-(Human Complement C5 Alpha-Chain) (Human-Mouse Monoclonal 5G1.1 Heavy Chain), Disulfide with Human-Mouse Monoclonal 5G.1.1 Light Chain, Dimer, monoclonal antibody anti-C5, h5G1.1 
A monoclonal antibody used to prevent red blood cells from being destroyed in patients with paroxysmal nocturnal hemoglobinuria (PNH), a red blood… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
BACKGROUND Atypical hemolytic-uremic syndrome is a genetic, life-threatening, chronic disease of complement-mediated thrombotic… (More)
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Highly Cited
2012
Highly Cited
2012
BACKGROUND AND OBJECTIVES The principle defect in dense deposit disease and C3 glomerulonephritis is hyperactivity of the… (More)
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Highly Cited
2011
Highly Cited
2011
n engl j med 364;26 nejm.org june 30, 2011 2561 The author replies: Miller and colleagues are correct that pharmacists can be a… (More)
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Highly Cited
2009
Highly Cited
2009
n engl j med 360;5 nejm.org january 29, 2009 544 observed reduction in the plasma level of factor H to 180 μg per milliliter… (More)
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Highly Cited
2009
Highly Cited
2009
n engl j med 360;5 nejm.org january 29, 2009 542 myocardial infarction or coronary death, a 24% decrease in the need for coronary… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND AND OBJECTIVES Atypical hemolytic uremic syndrome (aHUS) is associated with a congenital or acquired dysregulation of… (More)
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Highly Cited
2008
Highly Cited
2008
The terminal complement inhibitor eculizumab was recently shown to be effective and well tolerated in patients with paroxysmal… (More)
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Highly Cited
2007
Highly Cited
2007
The complement system provides critical immunoprotective and immunoregulatory functions but uncontrolled complement activation… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND We tested the safety and efficacy of eculizumab, a humanized monoclonal antibody against terminal complement protein… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Paroxysmal nocturnal hemoglobinuria (PNH) arises from a somatic mutation of the PIG-A gene in a hematopoietic stem… (More)
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